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Ferrets (Laboratory) - Pathology (view source)
Revision as of 15:33, 2 March 2011
, 15:33, 2 March 2011→Nervous System
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==Nervous System==
==Nervous System==
'''Canine Distemper'''
This morbillivirus is essentially 100% fatal in ferrets and disease progression can range from 12 to 42 days. This disease is immunosuppressive and animals die from neurologic dysfunction. Treatment is not recommended. There is one approved distemper vaccine in the US (Fervac-D) which is commercially produced. The presence of suppurative bronchopneumonia in young ferrets is suggestive of this disease.
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Gross lesions will be similar to those found in canines. Animals will suffer photophobia (excessive sensitivity to light). Gross lesions will include oculonasal discharge, hyperkaratosis of the planum nasale and footpads, papular rashs around chin and bronchopneumonia. Microscopic lesions will include brightly eosinophilic intracytoplasmic and intranuclear inclusions often in epithelial cells, neurons, WBCs and megakaryocytes. (Studies have shown that the biliary epithelium, urinary bladder and renal pelvis are the most productive places to look for these inclusions. A non-suppurative encephalitis with de-mylination may also be seen.
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