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Ferrets (Laboratory) - Pathology (view source)
Revision as of 16:56, 2 March 2011
, 16:56, 2 March 2011→General GI
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There are two distinct types of gastric ulcer in ferrets. The most common is associated with the presence of digested blood in the lumen of the stomach. All types of ulcers will be pin point and difficult to see with the naked eye. They will be in highest numbers in the pylorus. Microscopic ulcer lesions will appear as full thickness areas of glandular necrosis and loss which are well demarcated from the surrounding tissue. Bleeding ulcers will be coated with a layer of brown haemoglobin pigment.
There are two distinct types of gastric ulcer in ferrets. The most common is associated with the presence of digested blood in the lumen of the stomach. All types of ulcers will be pin point and difficult to see with the naked eye. They will be in highest numbers in the pylorus. Microscopic ulcer lesions will appear as full thickness areas of glandular necrosis and loss which are well demarcated from the surrounding tissue. Bleeding ulcers will be coated with a layer of brown haemoglobin pigment.
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'''Inflammatory Bowel Disease'''
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IBD is very common in middle to old age ferrets and generally falls into two categories; a lymphocytic/plasmacytic form and an eosinophilic form (also known as eosinophilic gastroenteritis). The causes of IBD are multifactorial and the nature of the disease is an uncontrolled inflammatory reaction in the intestine. Strong evidence exists that infections by ''helicobacter mustelae'' and ferret coronavirus may eventually result in this condition.
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Gross lesions are not normally associated with IBD, aside from generally inflammed GI tract lining. Microscopic lesions will include small to moderate numbers of lymphocytes, plasma cells and eosinophils, mainly within the small intestine. Lymphocytic forms of IBD are associated with intramucosal lymphocytes and villi atrophy, blunting and fusion. Microscopic lesions associated with the eosinophilic form include eosinophilic infiltrates within the small intestine. Additionally, prominent eosinophilic infiltrates may be seen in the mesenteric lymph nodes, liver, pancreas or other abdominal organs.
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