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Ferrets (Laboratory) - Pathology (view source)
Revision as of 21:36, 2 March 2011
, 21:36, 2 March 2011→Hematolymphatic System
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Microscopic lesions in the adult form (lymphocytic) can be seen by undertaking biopsy of peripheral lymph nodes. These will reveal effacement of the normal lymph node architecture by an infiltrate of small non-cleaved lymphocytes which breach the capsule and reach into the surrounding tissue. There may also be "tingible" (found in lymph nodes) macrophages scattered throughout the node. Neoplastic infiltrates can also be found in the portal areas of the liver. In the juvenile form (lymphoblastic), the examination of visceral organs will reveal effacement of any normal architecture by a monomorphic population of large cleaved and non-cleaved lymphoblasts. In the liver neoplastic cells can often be seen as discrete nodules.
Microscopic lesions in the adult form (lymphocytic) can be seen by undertaking biopsy of peripheral lymph nodes. These will reveal effacement of the normal lymph node architecture by an infiltrate of small non-cleaved lymphocytes which breach the capsule and reach into the surrounding tissue. There may also be "tingible" (found in lymph nodes) macrophages scattered throughout the node. Neoplastic infiltrates can also be found in the portal areas of the liver. In the juvenile form (lymphoblastic), the examination of visceral organs will reveal effacement of any normal architecture by a monomorphic population of large cleaved and non-cleaved lymphoblasts. In the liver neoplastic cells can often be seen as discrete nodules.
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'''Aleutian Disease'''
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Aleutian disease is caused by a parvovirus and results in hypergammaglobulinemia and in late stages glomerulonephritis, although the disease can take up to two years for this to occur. In the late stages of the disease, ferrets will be hyperproteinaemic with this being almost totally made up of gammaglobulins.
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Gross lesions can only be seen in the late stages of the disease with splenomegaly and lymphadenopathy the most common signs. Enlarged brown-tan kidneys may also be present. Microscopic lesions can include prominent plasmacytic infiltrates seen in numerous organs but particularly in the renal interstitium, hepatic portal areas and in the splenic red pulp. In addition there may also be marked plasmacytosis of numerous lymph nodes and the bone marrow. In the majority of cases there will also be membranous glomerulonephritis. Vasculitis can also be seen in almost any organ.
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