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*Giant breeds of dog are at massively increased risk
*Giant breeds of dog are at massively increased risk
*Clinical signs:
*Clinical signs:
**Painful swellings of bones in mature individuals (contrast with [[Panosteitis|panosteitis]] and [[Bones Hyperplastic and Neoplastic - Pathology#Hypertrophic osteodystrophy|hypertrophic osteodystrophy]])
**Painful swellings of bones in mature individuals (contrast with [[Panosteitis|panosteitis]] and [[Hypertrophic Osteodystrophy|hypertrophic osteodystrophy]])
*Strong site preference in dogs:
*Strong site preference in dogs:
**Appendicular skeleton 3 or 4 times more frequently involved than axial
**Appendicular skeleton 3 or 4 times more frequently involved than axial