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*No causative agent has been found
 
*No causative agent has been found
 
*Seem to be immune-mediated diseases
 
*Seem to be immune-mediated diseases
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===Erosive===
 
===Erosive===
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====Rheumatoid arthritis====
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====[[Rheumatoid Arthritis]]====
*Occurs in the dog, mainly smaller breeds
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*Uncommon
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*Progressive erosive polyarthritis
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*Mostly involves elbows, stifles, carpal and tarsal joints
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*Grossly:
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**Marked villus hypertrophy of synovial membrane
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**Cartilage erosion
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**[[Musculoskeletal Terminology - Pathology|Pannus and periarticular osteophyte]] formation
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**In severe cases ankylosis
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*Histologically:
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**Hyperplasia of lining cells
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**Proliferative synovitis
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**Synovial membrane has fibrin deposits
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**Lymphoid and plasma cell infiltration
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**Surrounding haemorrhagic areas
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**Macrophages containing [[Pigmentation - Pathology#Haemosiderin|haemosiderin]]
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**Connective tissue may contain foci of necrosis
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**Areas of erosion of peripheral articular cartilage and underlying subchondral bone
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*Pathogenesis:
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**May involve deposition of immune complexes within joints
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**Substances degrading cartilage are released by synovial cells and macrophages involved in pannus formation
       
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