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Created page with "*'''Malignant hyperthermia''' *Pigs, dogs, humans *Possibly a cellular defect resulting in high intacellular calcium ion concentration **-> Activates myofibrillar ATPase -> rapid..."
*'''Malignant hyperthermia'''
*Pigs, dogs, humans
*Possibly a cellular defect resulting in high intacellular calcium ion concentration
**-> Activates myofibrillar ATPase -> rapid intracellular glycolysis -> increase in body heat -> denature protein -> cell death -> leakage of cellular content -> oedema
*Grossly:
**Muscles are pale, soft and exudative
*Histologically:
**Segmental hypercontraction
**Monophasic, multifocal [[Muscles Degenerative - Pathology#Necrosis|segmental necrosis]]
*Inherited
*Triggered by halothane anaesthesia, stress of handling, transportation or slaughter
[[Category:Muscles - Developmental Pathology]]
*Pigs, dogs, humans
*Possibly a cellular defect resulting in high intacellular calcium ion concentration
**-> Activates myofibrillar ATPase -> rapid intracellular glycolysis -> increase in body heat -> denature protein -> cell death -> leakage of cellular content -> oedema
*Grossly:
**Muscles are pale, soft and exudative
*Histologically:
**Segmental hypercontraction
**Monophasic, multifocal [[Muscles Degenerative - Pathology#Necrosis|segmental necrosis]]
*Inherited
*Triggered by halothane anaesthesia, stress of handling, transportation or slaughter
[[Category:Muscles - Developmental Pathology]]