Changes

*Creatine kinase (CK) is an enzyme which leaks following injury  

*Creatine kinase (CK) is an enzyme which leaks following injury  

**Used to measure the extent of muscle damage

**Used to measure the extent of muscle damage

*Often is followed by [[Muscle Regeneration - Anatomy & Physiology|regeneration]]

*Often is followed by [[Muscle Regeneration|regeneration]]

*Histologically:

*Histologically:

**Hyaline hypercontracted fiber rounded at cross-section and increased diameter and eosin staining

**Hyaline hypercontracted fiber rounded at cross-section and increased diameter and eosin staining

**Histologically:

**Histologically:

***Segmental necrosis, no calcification

***Segmental necrosis, no calcification

***[[Muscle Regeneration - Anatomy & Physiology|Regeneration]] may occur in surviving animals

***[[Muscle Regeneration|Regeneration]] may occur in surviving animals

*'''Drugs'''

*'''Drugs'''

**E.g. corticosteroids, cholinesterase inhibitors, vincristine, dimethyl sulfoxide (DMSO)

**E.g. corticosteroids, cholinesterase inhibitors, vincristine, dimethyl sulfoxide (DMSO)

***Histologically:

***Histologically:

****[[Muscles Degenerative - Pathology#Necrosis|Segmental necrosis]]

****[[Muscles Degenerative - Pathology#Necrosis|Segmental necrosis]]

****Possibly [[Muscle Regeneration - Anatomy & Physiology|regeneration]] in surviving animals

****Possibly [[Muscle Regeneration|regeneration]] in surviving animals

***Can cause rapid onset recumbency and potentially death  

***Can cause rapid onset recumbency and potentially death  

***Usually due to mixing errors in feed

***Usually due to mixing errors in feed

**Pigs also have lesions in their [[Hyaline Degeneration|heart]] and [[Liver Fibrosis#Hepatosis dietica|liver]]

**Pigs also have lesions in their [[Hyaline Degeneration|heart]] and [[Liver Fibrosis#Hepatosis dietica|liver]]

*Histologically:

*Histologically:

**[[Muscles Degenerative - Pathology#Necrosis|Segmental necrosis]] +/- [[Muscles Degenerative - Pathology#Calcification|calcification]] and [[Muscle Regeneration - Anatomy & Physiology|regeneration]]

**[[Muscles Degenerative - Pathology#Necrosis|Segmental necrosis]] +/- [[Muscles Degenerative - Pathology#Calcification|calcification]] and [[Muscle Regeneration|regeneration]]

**Multifocal and multiphasic lesions

**Multifocal and multiphasic lesions