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Created page with "*Necrosis of an entire myofibre is uncommon *Segmental necrosis is more typical *Muscle cell contents may leak into the blood if the cell membrane is damaged *Creatine kinase (CK..."
*Necrosis of an entire myofibre is uncommon
*Segmental necrosis is more typical
*Muscle cell contents may leak into the blood if the cell membrane is damaged
*Creatine kinase (CK) is an enzyme which leaks following injury
**Used to measure the extent of muscle damage
*Often is followed by [[Muscle Regeneration|regeneration]]
*Histologically:
**Hyaline hypercontracted fiber rounded at cross-section and increased diameter and eosin staining
***May also be an artifact due to hypercontraction of normal fibres at fixation
**Fragmenting portions of fibre -> floccular or granular
**Normal portion of fibre may detach from necrotic part -> retraction caps
**Infarction may cause '''discoid degeneration''' - necrotic fibres detach at '''Z lines'''
**May [[Muscles Degenerative - Pathology#Calcification|mineralise]]
*[[Zenker Degeneration - Pathology|'''Zenker's degeneration''']] - secondary to systemic disease
**Scattered small segments of necrosis and fast regeneration
**Sacrolemmal tubes are intact
[[Category:Muscles - Degenerative Pathology]]
*Segmental necrosis is more typical
*Muscle cell contents may leak into the blood if the cell membrane is damaged
*Creatine kinase (CK) is an enzyme which leaks following injury
**Used to measure the extent of muscle damage
*Often is followed by [[Muscle Regeneration|regeneration]]
*Histologically:
**Hyaline hypercontracted fiber rounded at cross-section and increased diameter and eosin staining
***May also be an artifact due to hypercontraction of normal fibres at fixation
**Fragmenting portions of fibre -> floccular or granular
**Normal portion of fibre may detach from necrotic part -> retraction caps
**Infarction may cause '''discoid degeneration''' - necrotic fibres detach at '''Z lines'''
**May [[Muscles Degenerative - Pathology#Calcification|mineralise]]
*[[Zenker Degeneration - Pathology|'''Zenker's degeneration''']] - secondary to systemic disease
**Scattered small segments of necrosis and fast regeneration
**Sacrolemmal tubes are intact
[[Category:Muscles - Degenerative Pathology]]