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| | ==Nutritional myopathy== | | ==Nutritional myopathy== |
| − | [[Image:White muscle disease.jpg|right|thumb|100px|<small><center>White muscle disease (Image sourced from Bristol Biomed Image Archive with permission)</center></small>]]
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| − | [[Image:White muscle disease histo.jpg|right|thumb|100px|<small><center>White muscle disease (Image sourced from Bristol Biomed Image Archive with permission)</center></small>]]
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| | ===[[White Muscle Disease - Pathology|White muscle disease]]=== | | ===[[White Muscle Disease - Pathology|White muscle disease]]=== |
| − | *Very important economic disease of sheep, cattle and pig
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| − | *Caused by:
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| − | **Deficiency of selenium, vitamin E or both
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| − | **Exacerbated by rapid growth, unaccustomed exercise or other dietary factor
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| − | *Pathogenesis:
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| − | **Oxygen free radicals (OFR) can damage cell membranes
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| − | **Vitamin E usually mops up OFRs
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| − | **Selenium as part of glutathione peroxidase neutralises effects of OFRs
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| − | **If Vit E or Se are deficient -> the balance shifts to membrane damage, calcium entry and mitochondrial damage -> cell swells and dies -> segmental muscle [[Muscles Degenerative - Pathology#Necrosis|necrosis]]
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| − | *Grossly:
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| − | **Lesions are bilaterally symmetrical in hard working muscles (vary with species)
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| − | **Early lesions are pale areas and streaks
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| − | ***Difficult to see especially in pale muscles
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| − | **Later becoming calcified necrotic areas
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| − | ***More obvious
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| − | **Pigs also have lesions in their [[Hyaline Degeneration|heart]] and [[Liver Fibrosis#Hepatosis dietica|liver]]
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| − | *Histologically:
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| − | **[[Muscles Degenerative - Pathology#Necrosis|Segmental necrosis]] +/- [[Muscles Degenerative - Pathology#Calcification|calcification]] and [[Muscle Regeneration|regeneration]]
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| − | **Multifocal and multiphasic lesions
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| − | [[Category:Muscles - Degenerative Pathology]]
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