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Created page with "(MMM) *Occurs in dogs *Tends to affect the masseter and temporalis muscles *Autoantibodies selectively attack muscles of mastication (type IIM fibres) *Acute stage = eosinophilic..."
(MMM)
*Occurs in dogs
*Tends to affect the masseter and temporalis muscles
*Autoantibodies selectively attack muscles of mastication (type IIM fibres)
*Acute stage = eosinophilic myositis
**Extremely swollen, painful, hard masticatory muscles
*Chronic stage = atrophic myositis
**Atrophy may occur without previous acute stage
*Grossly:
**Bilateral but not necessarily symmetrical
**At first, enlarged and oedematous muscles becominf dark red, firm with reddish streaks and yellowiss foci
*Histologically:
**Acute lesions:
***Mainly eosinophilic infiltrate, few lymphocytes, [[Monocytes|monocytes]] and plasma cells
***In recurrent disease plasma cells predominate
***[[Muscle Necrosis|Necrotic]] myofibres, [[Muscle Atrophy|atrophy]] and attempted [[Muscle Regeneration|regeneration]]
**Chronic stage:
***[[Muscle Atrophy|Atrophy]] predominates
***Fasciculi are shrunken
***Condensation of stroma -> enlarged endomysium
***Focal plasma cell and lymphocyte infiltration
[[Category:Muscles - Inflammatory Pathology]]
*Occurs in dogs
*Tends to affect the masseter and temporalis muscles
*Autoantibodies selectively attack muscles of mastication (type IIM fibres)
*Acute stage = eosinophilic myositis
**Extremely swollen, painful, hard masticatory muscles
*Chronic stage = atrophic myositis
**Atrophy may occur without previous acute stage
*Grossly:
**Bilateral but not necessarily symmetrical
**At first, enlarged and oedematous muscles becominf dark red, firm with reddish streaks and yellowiss foci
*Histologically:
**Acute lesions:
***Mainly eosinophilic infiltrate, few lymphocytes, [[Monocytes|monocytes]] and plasma cells
***In recurrent disease plasma cells predominate
***[[Muscle Necrosis|Necrotic]] myofibres, [[Muscle Atrophy|atrophy]] and attempted [[Muscle Regeneration|regeneration]]
**Chronic stage:
***[[Muscle Atrophy|Atrophy]] predominates
***Fasciculi are shrunken
***Condensation of stroma -> enlarged endomysium
***Focal plasma cell and lymphocyte infiltration
[[Category:Muscles - Inflammatory Pathology]]