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Ferrets (Laboratory) - Pathology (view source)
Revision as of 14:48, 4 March 2011
, 14:48, 4 March 2011→Urinary System
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Gross lesions may include single or multiple cysts present within the cortex of one or both kidneys. Cysts may range up to 1cm in diameter. Polycystic kidneys may be markedly enlarged and fill the posterior abdomen. Microscopic lesions can include thick walls of fibrous tissue surrounding cysts resulting in numerous atrophic glomeruli and tubules.
Gross lesions may include single or multiple cysts present within the cortex of one or both kidneys. Cysts may range up to 1cm in diameter. Polycystic kidneys may be markedly enlarged and fill the posterior abdomen. Microscopic lesions can include thick walls of fibrous tissue surrounding cysts resulting in numerous atrophic glomeruli and tubules.
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'''Chronic Interstitial Nephritis'''
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Chronic interstitial nephritis is a common finding in ferrets and lesions can be seen as early as age two. Advanced cases may result in renal failure and can occur as early as age four. The progression of this disease is very similar to that found in older cats.
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Gross lesions will include pitted kidneys with large focal depressions in the outer cortex, formed as a result of scar tissue. Removal of the renal capsule during necropsy is recommended. The size of the kidneys may also be asymmetric. Microscopic changes associated with this disease in ferrets are unique. At low magnifications there will be linear bands of fibrosis extending from the outer capsule towards the medulla. Where these fibrotic changes have occurred, tubule and glomerular changes will also be visible. There will be glomerularsclerosis within the periglomerular region. The intersititium of the kidney will also contain fibrotic tissue together with moderate numbers of lymphocytes and plasma cells. These microscopic findings are very similar to chronic infarction. Areas of fibrosis tend to coalesce into large areas on non-functional glomeruli and tubules.
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