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Ferrets (Laboratory) - Pathology (view source)
Revision as of 15:31, 4 March 2011
, 15:31, 4 March 2011→Reproductive System
==Reproductive System==
==Reproductive System==
'''Oestrous-associated Aplastic Anemia'''
'''Oestrous-associated Aplastic Anemia'''
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As ferrets are induced ovulators, intact females will remain in oestrous until mated or spayed. Half of un-mated jills will develop marked bone marrow suppression as a result of these high levels of oestrogen. Erythrocytes, leukocytes and megakaryocytes will all be affected. During the early stages, there will be mild thrombocytosis and leukocytosis but in cases that have progressed there will be a non-regenerative anaemia, leukopenia and thrombocytopenia. A liver-associated clotting abnormality has also been reported with oestrous-associated aplastic anemia.
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Gross lesions will include a prominently swollen vulva. Associated signs of hyperoestrogenism will include pale mucus membranes, alopecia, thin watery blood, haemorrhages throughout the body, pyometra, bronchopneumonia and vaginitis. Microscopic lesions will include aplastic anemia (PCV <20%). Characteristic lesions will include hypocellularity of the bone marrow and some evidence of haemorrhage in lymph nodes and spleen. Supparative metritis or pneumonia may also be seen as a result of the leukopenia.
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