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Ferrets (Laboratory) - Pathology (view source)
Revision as of 16:24, 4 March 2011
, 16:24, 4 March 2011→Respiratory System
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Gross lesions will include pitted kidneys with large focal depressions in the outer cortex, formed as a result of scar tissue. Removal of the renal capsule during necropsy is recommended. The size of the kidneys may also be asymmetric. Microscopic changes associated with this disease in ferrets are unique. At low magnifications there will be linear bands of fibrosis extending from the outer capsule towards the medulla. Where these fibrotic changes have occurred, tubule and glomerular changes will also be visible. There will be glomerularsclerosis within the periglomerular region. The intersititium of the kidney will also contain fibrotic tissue together with moderate numbers of lymphocytes and plasma cells. These microscopic findings are very similar to chronic infarction. Areas of fibrosis tend to coalesce into large areas on non-functional glomeruli and tubules.
Gross lesions will include pitted kidneys with large focal depressions in the outer cortex, formed as a result of scar tissue. Removal of the renal capsule during necropsy is recommended. The size of the kidneys may also be asymmetric. Microscopic changes associated with this disease in ferrets are unique. At low magnifications there will be linear bands of fibrosis extending from the outer capsule towards the medulla. Where these fibrotic changes have occurred, tubule and glomerular changes will also be visible. There will be glomerularsclerosis within the periglomerular region. The intersititium of the kidney will also contain fibrotic tissue together with moderate numbers of lymphocytes and plasma cells. These microscopic findings are very similar to chronic infarction. Areas of fibrosis tend to coalesce into large areas on non-functional glomeruli and tubules.
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==Cardiovascular System==
'''Cardiomyopathy'''
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Several forms of this disease can be seen in ferrets; dilative, hypertrophic and a restrictive form where there is marked replacement of the myocardium with fibrous connective tissue. Signs of myocardiopathy can be seen as early as age one but are most common between age five and seven.
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Gross lesions in sub-clinical cases may include a congested and occasionally nodular liver, the heart may be enlarged and the right ventricle may appear thin or flabby. In severe cases gross lesions may include an accumulation of serosanguinous ascitic transudate in the abdominal cavity and/or the pleural cavity. The lungs may also be atelectatic (lack of gas exchange within alveoli, due to alveolar collapse or fluid consolidation) and compressed by the heart. There may also be significant pleural effusion. Microscopic lesions in early cases will include an increase in fibrous connective tissue around myocardial vessels that may extend into the interstitium. In advanced cases there will be atrophy and loss of myocytes. Within focal areas of myocyte denegeration there may also be moderate numbers of macrophages, lymphocytes, plasma cells and rare neutrophils. Signs of liver congestion such as fibrosis will may also be present. In terminal cases there may be necrosis of centrilobular hepatocytes due to stasis and hypoxia.
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===Adenovirus===
===Adenovirus===
==Digestive System==
==Digestive System==