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CNS Response to Injury - Pathology (view source)
Revision as of 12:31, 8 March 2011
, 12:31, 8 March 2011no edit summary
==Introduction==
==Introduction==
*#* Choroid plexus epithelial cells
*#* Choroid plexus epithelial cells
* The response to injury varies with the cell type injured.
* The response to injury varies with the cell type injured.
==Response of Neurons to Injury==
==[[Neuron Response to Injury]]==
* Neurons are particularly vulnerable to injury, due to their:
* Neurons are particularly vulnerable to injury, due to their:
** It may sometimes be a normal feature.
** It may sometimes be a normal feature.
==Glial Cell Response to Injury==
[[Category:CNS Response to Injury]]
==[[Glial Cell Response to Injury]]==
* The order of susceptibility of CNS cells to injury runs, from most to least susceptible:
* The order of susceptibility of CNS cells to injury runs, from most to least susceptible:
*#* These are small nodules that occur notably in viral diseases.
*#* These are small nodules that occur notably in viral diseases.
==General Responses to Injury==
[[Category:CNS Response to Injury]]
==[[General CNS Responses to Injury]]==
===Ischaemic Damage===
===Ischaemic Damage===
*** Cyanide poisoning, which inhibits tissue respiration
*** Cyanide poisoning, which inhibits tissue respiration
==Excitotoxicity==
[[Category:CNS Response to Injury]]
==[[Excitotoxicity]]==
* The term "excitotoxicity" is used to describe the process by which neurons are damaged by glutamate and other similar substances.
* The term "excitotoxicity" is used to describe the process by which neurons are damaged by glutamate and other similar substances.
*#*** These enzymes go on to damage cell structures such as components of the cytoskeleton, membrane, and DNA.
*#*** These enzymes go on to damage cell structures such as components of the cytoskeleton, membrane, and DNA.
* Excitotoxicity is, therefore, a cause of acute neuron death.
* Excitotoxicity is, therefore, a cause of acute neuron death.
[[Category:CNS Response to Injury]]