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[[Liver_Flashcards_-_Pathology|Liver Pathology Flashcards]]
[[Liver_Flashcards_-_Pathology|Liver Pathology Flashcards]]
+(LSD)
+* Occurs in many breeds of dogs and cats.
+* Genetic defects give deficiencies of specific enzymes of degradation.
+** Disease only occurs in animals homozygous at the gene pair controlling enzyme activity.
+*** The genes are co-dominant.
+** Enzyme activity is extremely low or entirely absent.
+* Large amounts of waste products accumulate within cells.
+** Nervous system cells are predisposed.
+** Cells become engorged.
+** Normal function is prevented.
+* [http://w3.vet.cornell.edu/nst/nst.asp?Fun=Display&imgID=20531 Image 1, courtesy of Cornell Veterinary Medicine] <BR>
+* [http://w3.vet.cornell.edu/nst/nst.asp?Fun=Display&imgID=20530 Image 2, courtesy of Cornell Veterinary Medicine]
+* [http://w3.vet.cornell.edu/nst/nst.asp?Fun=Display&imgID=20185 Image 3, courtesy of Cornell Veterinary Medicine]
+===Clinical Signs===
+* Nervous system cells are predisposed to the disease, and so progressive neurological signs predominate.
+** Develop between 2 weeks and 12 months of age.
+** The disease is ultimately fatal.
+* For example, Siamese cats show:
+** Ganglisidosis
+** Mucopolysaccharidosis
+
+===Diagnosis===
+
+* Clinical signs are considered.
+* Urine enzyme assays may be helpful.
+* Post-mortem diagnosis is possible.
+* More recently, gene tests have been available.
==References==
==References==
+
+
+[[Category:Central Nervous System - Degenerative Pathology]]
[[Category:Liver - Storage Diseases]]
[[Category:Liver - Storage Diseases]]
[[Category:To_Do_-_Clinical]]
[[Category:To_Do_-_Clinical]]