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CNS Degenerative Diseases - Pathology (view source)

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==[[Cognitive Dysfunction Syndrome]] ==

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~~(CDS)~~

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* CDS causes signs of senility.

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* Increasing numbers of dogs and cats are suffering from CDS.

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** Prevalence is similar to that seen in humans: an 85 year-old human is roughly equivalent to a 15 year-old cat, and a 13-14 year-old dog.

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*** Aging in dogs id breed specific.

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~~===Pathology===~~

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* A number of changes are seen in the brains of geriatric animals which may cause the signs of CDS.

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** Vascular insufficiency leads to:

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*** Hypoxia

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*** Increased free redical production

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*** Deposition of amyloid plaques

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*** Modification of other brain proteins

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~~===Treatment===~~

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* There are no published studies related to treatment of CDS in animals.

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* Potential therapies include:

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** Dietary modification

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*** Diets are enriched with antioxidants, vitamin E, beta-carotene and essential fatty acids.

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** Environmental stimulation

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** Drugs

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*** Selegiline

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*** Propentofylline

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*** Nicergoline

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~~[[Category:Central Nervous System - Degenerative Pathology]]~~

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CNS Degenerative Diseases - Pathology (view source)

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