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== Introduction<br> ==
====Antigenicity====
This is a notifiable disease of horses in the UK caused by Equine Arteritis Virus. The disease infects the nasopharynx after respiratory transmission, causing a multitude of respiratory signs. The disease can also be spread venerally. After this, the virus spread to lymphoid tissue leading to<span style="font-weight: bold;"> </span>'''leukopenia''' and '''immunosuppression'''. Then it disseminates through the circulatory system causing medial necrosis of arteries occurs causing haemorrhages and abortions, as well as oedema.<br>
Many cases are subclinical and only '''antibody positive.'''
The disease is controlled virus in the UK but AI and breeding schemes presents a real risk.<br>
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====Epidemiology====
== Signalment<br> ==
More common in '''thoroughbreds '''than other breeds of horse. Most commonly seen in studs or in brood mares.
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== Clinical Signs<br> ==
Respiratory signs often appear first and these include dyspnoea, coughing and increased respiratory rate. This can also lead to interstitial pneumonia. In foals, interstitial pneumonia is the most common cause of death related to this disease. Once circulatory dissemination has occured, diarrhoea, colic and haemorrhage will occur. Abortions occur after 10-30 days in 50% of pregnant mares (as opposed to Equine Herpes, which shows late abortions). Oedema - particularly ocular odema is frequently present, giving rise to "pink eye". There will also be a pyrexia, rashes, ocular and nasal discharge, swelling of legs or scrotum ans stiffness of gait.
Stallions become intermittent or persistent '''shedders''' from [[Accessory Sex Glands - Anatomy & Physiology|accessory sex glands]] but may show no clinical signs.
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== Diagnosis ==
Clinical symptoms are the usual indicator of the disease, but these may be variable.
A '''PCR''' on '''semen '''or an '''ELISA''' for serum '''antibody '''can be used to gain a definative diagnosis.
[[Category:To_Do_-_Clinical/Viruses]]
[[Category:Respiratory_Viral_Infections]]
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[[Category:Respiratory Diseases - Horse]]
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== Control ==
'''Vaccine'''tallions require '''Live attenuated''' vaccine and mares require '''Killed whole virus. '''<span style="font-weight: bold;"> </span>Seropositive stallions restricted from teasing, mating or AI unless PCR tested negative. Persistent shedders should be castrated and serology should be performed on imported horses. Mares are tested within 4 weeks of mating.
Clinical disease is NOTIFIABLE.
In an outbreak, isolate and restrict movement until antibody-negative for one month <br>
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== References<br> ==
Mair, T., Love, S., Schumacher, J. and Watson, E. (1998) Equine Medicine, Surgery and Reproduction WB Saunders Company Ltd<br>Merck & Co (2008) The Merck Veterinary Manual (Eighth Edition) Merial <br>Reed, S.M, Bayly, W.M. and Sellon, D.C (2010) Equine Internal Medicine (Third Edition), Saunders.<br>Reed, S.M, Bayly, W.M, Sellon, D.C. (2004) Equine Internal Medicine (Second Edition) Saunders.<br>Robinson, N.E., Sprayberry, K.A. (2009) Current Therapy in Equine Medicine (Sixth Edition) Saunders Elsevier<br>Rose, R. J. and Hodgson, D. R. (2000) Manual of Equine Practice (Second Edition) Sauders. <br><br>
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[[Category:To_Do_-_Review]] [[Category:Respiratory_Viral_Infections]] [[Category:Respiratory_Diseases_-_Horse]]