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== Introduction<br>  ==
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CAEV
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This disease is caused by a virus from the family retrovirus (lentivirus) and is serologically related to Maedi- Visna virus described in sheep. They have different antigenic and genetic envelopes. This virus affects goats only.<br>
====Antigenicity====
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*Serologically related to [[Visna-Maedi Virus|Visna-Maedi]] with antigenic and genetic envelope differences
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====Hosts====
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This disease is characterised by an immune complex induced by T cells. Transfer is by milk and colostrum, particularly batch mixing from antibody positive dams. The disease is present in roughly 10% of UK herds, however clinical disease is rare.<br>
*Goats
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====Pathogenesis====
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<br>
*T cells induce immune complex disease
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*Causes '''encephalitis of kids''' or  [[Infectious Arthritis#In Goats|'''insidious polyarthritis of adults''']]
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*Also causes pneumonia
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====Epidemiology====
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== Signalment<br> ==
*Transfer via '''milk and colostrum''', particularly batch-mixing
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*Present in 10% of UK herds
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*Clinical disease is '''rare'''
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====Diagnosis====
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Goats contract the disease as kids, but clinical disease can be seen then, or adults.<br>
*Visna-Maedi serology (ELISA) test can be used to remove positive stock
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====Control====
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<br>
*Separate kids from virus positive mothers at birth
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*Treat mother's '''colostrum''' (56 deg for 1 hour)
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*Rear on artificial milk
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== Clinical Signs<br> ==
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There are two forms that the disease can take, depending on the age of the animal. In kids a non- suppurative leukoencephalomyelitis occurs, whereas in adult goats chronic, non- suppurative arthritis occurs. The virus also causes interstitial pneumonia which tends to be obscured by other clinical signs.
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===Caprine Arthritis-Encephalitis (CAE)===
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<br>
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*Caused by [[Retroviridae|retrovirus (lentivirus)]] similar to [[Visna-Maedi Virus|Maedi Visna]] in sheep described above
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== Diagnosis ==
*Two forms:
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**Non-suppurative leukoencephalomyelitis in young goats and kids
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**Chronic, non-suppurative arthritis-synovitis in adult goats
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*Also causes [[Interstitial Pneumonia|interstitial pneumonia]] which tends to be obscured by other clinical signs
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*Gross pathology:
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**Mainly caudal lobes
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**Lungs are firm, grey-pink with grey-white focal lesions on cut surface
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*Micro pathology:
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**Thickened alveolar wall
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**Lymphocyte infiltration and type II pneumocyte hyperplasia
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*Can be confused with or coexisting with [[Verminous Pneumonia|Parasitic pneumonia]]
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In older goats where pantropic arthritis occurs, this disease is usually suspected.<br>
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The Visna-Maedi serology (ELISA) test can be used to remove positive stock.<br>
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**Arthritis is commonly the main expression
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Post mortem examination can be performed. Signs characteristic of the disease include firm lungs, especially caudel lobes, pink- grey focal lesions are found here. On micro-pathology there will be a thickened alveolar wall, lymphocyte infiltration and type II pneumocyte hyperplasia is also seen. this can be confused with or coexisting with parasitic pneumonia. In limbs, large limb joints are thickened and carpal hygroma is often present. There will also be cystic swelling on the cranial surface of the knee containing serous fluid. In advanced cases synovial fluid hypertrophy, necrosis, mineralisation and articular cartilage formation will be seen.<br>
**Large limb joints are thickened
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**'''Carpal hygroma''' is often present
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***Subcutaneous cystic swelling on cranial surface of the knee, contains serous fluid
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**In advanced cases
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***Synovial villus hypertrophy
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***Necrosis
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***Mineralisation
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***Mononuclear cell infiltration
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***[[Musculoskeletal Terminology - Pathology|Pannus]] formation
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***[[Joints - Anatomy & Physiology#Articular cartilage|Articular cartilage]] destruction
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[[Category:Lentiviruses]][[Category:Goat Viruses]][[Category:To_Do_-_Clinical/Viruses]]
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<br>
[[Category:Respiratory_Viral_Infections]]
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[[Category:Musculoskeletal Diseases - Goat]][[Category:Neurological Diseases - Goat]][[Category:Respiratory Diseases - Goat]]
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== Control ==
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In herds where the virus is known to exist, separate kids from virus positive mothers at birth and do not allow them to suckle. The mothers' colostrum can be treated (56 deg for 1 hour) OR rear the kids on artificial milk.<br>
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<br>
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== References<br> ==
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Blood, D.C. and Studdert, V. P. (1999) Saunders Comprehensive Veterinary Dictionary (2nd Edition) Elsevier Science<br>Bridger J and Russell, P (2007) Virology Study Guide, Royal Veterinary College<br>Merck &amp; Co (2008) The Merck Veterinary Manual (Eighth Edition) Merial<br>Radostits, O.M, Arundel, J.H, and Gay, C.C. (2000) Veterinary Medicine: a textbook of the diseases of cattle, sheep, pigs, goats and horses Elsevier Health Sciences<br>
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<br>
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<br>
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[[Category:Lentiviruses]] [[Category:Goat_Viruses]] [[Category:To_Do_-_Review]] [[Category:Respiratory_Viral_Infections]] [[Category:Musculoskeletal_Diseases_-_Goat]] [[Category:Neurological_Diseases_-_Goat]] [[Category:Respiratory_Diseases_-_Goat]]
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