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− | ===Murine Parainfluenza - 1 ([[Sendai Virus]])===
| + | Also known as: '''''Murine Parainfluenza - 1''''' |
− | *Endemic in many '''mouse''' colonies
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− | *Most mice show no symptoms due to maternal antibodies
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− | *But minor respiratory lesions may invalidate carcinogenic or toxicological studies
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− | *Immunological studies also confused due to virus activating [[Natural Killer cells|NK cells]] via high circulating [[Interferons|IF]] 3-4 days post-infection
| + | == Introduction == |
− | *Control achieved by:
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− | **Purchasing '''specific pathogen free (SPF)''' mice
| + | Sendai virus is of the family paramyxoviridae. It is endemic in '''mouse''' colonies worldwide, but rarely shows as a clinical disease as maternal anitbody is usually high so the disease rarely has clinical effects. |
− | **Kill whole colony in an outbreak -> disinfection -> formalin fumigation
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− | [[Category:Paramyxovirinae]][[Category:Rodents]] | + | |
− | [[Category:To_Do_-_Clinical/Viruses]] | + | |
| + | == Clinical Signs == |
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| + | There may be mild clinical signs related to the respiratory tract such as nasal discharge or coughing and increased respiratory rate. The animal may be inappentant and lethargic for a short period. |
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| + | == Diagnosis == |
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| + | Virus isolation is diagnostic. |
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| + | == Control == |
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| + | Control is achived by purchasing '''specific pathogen free (SPF)''' mice, which have been screened serologically as having not been exposed to many viruses and bacteria. This is obviously only avaliable in large scale laboratories. |
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| + | In the cases of an outbreak, the whole colony should be destroyed and disinfection and formalin fumigation should take place. |
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| + | == References == |
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| + | Blood, D.C. and Studdert, V. P. (1999) Saunders Comprehensive Veterinary Dictionary (2nd Edition), Elsevier Science <br>Bridger, J and Russell, P (2007) Virology Study Guide, Royal Veterinary College <br>Paterson, S (2006) Skin Diseases of Exotic Pets, Blackwell Publishing <br>Roberts, W.A. and Carter, G.A.(1976) Essentials of Veterinary Virology, Michigan State University Press, East Lansing, Michigan |
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| + | [[Category:Paramyxovirinae]] [[Category:Rodents]] [[Category:To_Do_-_Review]] |