Changes

===Fibrosis - Repair===

== Introduction ==

Any hepatic injury of a moderate degree or more, is going to cause a degree of fibrosis when the lesion has resolved. Fibrosis occurs due to proliferation of the supportive connective tissue in the liver. Fibrosis isolates the [[Liver - Anatomy & Physiology|liver]] cells by effectively changing the sinusoids into capillaries and when a certain amount of fibrosis occurs, it can be self-perpetuating, the end result is a small scarred [[Liver - Anatomy & Physiology|liver]] with functional failure.

 

== Types of fibrosis ==

*when a certain amount of fibrosis occurs, it can be self-perpetuating

====Histological patterns====

=====Periacinar fibrosis=====

=====Periacinar fibrosis=====

*the fibrosis surrounds the hepatic venule (centrilobular vein)

In this type of fibrosis, the fibrous area surrounds the hepatic venule (centrilobular vein). This can be seen when there is chronic passive congestion with atrophy of the surrounding periacinar hepatocytes and condensation of the remaining connective tissue.

*can be seen when there is chronic passive congestion with atrophy of the surrounding periacinar hepatocytes and condensation of the remaining connective tissue

 

=====Biliary fibrosis=====

=====Biliary fibrosis=====

*accompanying inflammation centered on the portal triads

This usually occurs along with another type of fibrosis and will accompany inflammation centered on the portal triads.

 

=====Post necrotic scarring=====

=====Post necrotic scarring=====

*following massive necrosis where the necrotic cells are removed and the defect is reapired by fibrosis

This type of fibrosis occurs following massive necrosis where the necrotic cells are removed and the defect is reapired by fibrosis. It is seen histopathologically as bands of fibrous tissue.

*seen as bands of fibrous tissue

 

=====Diffuse fibrosis=====

=====Diffuse fibrosis=====

*resulting from repeated damage to one or more zones

This occurs after repeated damage to one or more zones. The fibrosis generated proliferates throughout to involve all the tissue.

*the fibrosis generated proliferates throughout to involve all the tissue

 

 

[[Category:Liver_-_General_Pathology]]

[[Category:Liver_-_General_Pathology]]

[[Category:To_Do_-_Clinical]]

[[Category:To_Do_-_Review]]