Changes

==Introduction==

==Introduction==

Uraemia describes the clinical systemic syndrome that occurs in animals suffering from [[Kidney Renal Failure - Pathology|renal failure]].  Traditionally, uraemia was thought to be caused by [[Azotaemia|azotaemia]], an increase in the blood concentrations of urea and creatinine, but it is now apparent that multiple '''uraemic toxins''' cause derangements in many metabolic processes. Azotaemia is important in the diagnosis of uraemia but it is an insensitive indicator of renal failure, only becoming detectable when more than approximately two thirds of the nephrons are no longer functional.

Uraemia describes the clinical systemic syndrome that occurs in animals suffering from [[:Category:Renal Failure|renal failure]].  Traditionally, uraemia was thought to be caused by [[Azotaemia|azotaemia]], an increase in the blood concentrations of urea and creatinine, but it is now apparent that multiple '''uraemic toxins''' cause derangements in many metabolic processes. Azotaemia is important in the diagnosis of uraemia but it is an insensitive indicator of renal failure, only becoming detectable when more than approximately two thirds of the nephrons are no longer functional.

===Pathophysiology===

===Pathophysiology===