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[[Image:Equine Internal Medicine Q&A 21.jpg|centre|500px]]<br>

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'''A 14-year-old Thoroughbred gelding has a six-year history of a chronic cough and an intermittent nasal discharge. Thoracic auscultation revealed loud end expiratory wheezes. A tracheobronchial aspirate specimen is seen in the image.'''

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<FlashCard questions="3">
|q1=What are the cell types seen?
|a1=
*Macrophages,
*a Curshman spiral,
*a multinucleated giant cell,
*respiratory epithelial cells,
*mucus and
*debris.
|l1=
|q2=What is the likely diagnosis?
|a2=
Chronic obstructive pulmonary disease (COPD).
|l2=
|q3=What treatment is required?
|a3=
*The key means of controlling COPD is by reducing the horse’s exposure to the offending agents, most often airborne dust and moulds. <br><br>
*Pharmaceutical intervention may be necessary and could include the use of bronchodilators, mucolytics and anti-inflammatory agents. <br><br>
*Bronchodilators may include drugs from these three groups:
#muscarinic receptor antagonists – parasympatholytics;
#adrenoceptor agonists – sympathomimetics; and
#methylxanthine derivates. <br><br>
*Mucokinetic drugs increase the transport of the complex and incompletely understood airway secretions by differing mechanisms. <br><br>
*Mucokinetic agents to consider in the horse include
#bromhexine,
#dembrexine,
#theophylline and
#clenbuterol. <br><br>
*Anti-inflammatory drugs primarily affect the delayed response and bronchial hyperreactivity.<br><br>
*Corticosteriods most commonly used are
#prednisolone and
#dexamethasone.
|l3=

</FlashCard>

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