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Immune Mediated Thrombocytopaenia (view source)
Revision as of 11:35, 6 June 2011
, 11:35, 6 June 2011no edit summary
Also known as: '''''ITP — Idiopathic Thrombocytopaenic Purpura — [[Evan's syndrome|Evan’s Syndrome]]
Also known as: '''''ITP — Idiopathic Thrombocytopaenic Purpura — [[Evan's syndrome|Evan’s Syndrome]]
Definitive diagnosis relies on the detection of serum anti-platelet antibodies but this test is not widely available.
Definitive diagnosis relies on the detection of serum anti-platelet antibodies but this test is not widely available.
Other tests may also be used to exclude potential infectious causes of thrombocytopaenia such as ''[[Ehrlichia platys]]'' and ''Anaplasma phagocytophilum''.
Other tests may also be used to exclude potential infectious causes of thrombocytopaenia such as ''[[Ehrlichia platys]]'' and ''[[Anaplasma phagocytophilum]]''.
Faecal occult blood tests represent an unreliable way of detecting gastro-intestinal haemorrhage in cases of mild melaena. The animal must be deprived of meat, bismuth subsalicylate and ferrous sulphate for 3 days before the faecal samples are taken for analysis.
Faecal occult blood tests represent an unreliable way of detecting gastro-intestinal haemorrhage in cases of mild melaena. The animal must be deprived of meat, bismuth subsalicylate and ferrous sulphate for 3 days before the faecal samples are taken for analysis.
Similarly to IMHA, mortality is most likely in the initial stages of the disease and the mortality rate is approximately 30% in this period. Beyond this, the majority of animals recover well although they usually require tapered immunosuppressive treatment for roughly six months to completely control the disease. Initial responses to treatment are relatively quick, so if no increase in platelet number is seen within 1 week of initiating treatment, investigate further for an underlying cause which requires treatment.
Similarly to IMHA, mortality is most likely in the initial stages of the disease and the mortality rate is approximately 30% in this period. Beyond this, the majority of animals recover well although they usually require tapered immunosuppressive treatment for roughly six months to completely control the disease. Initial responses to treatment are relatively quick, so if no increase in platelet number is seen within 1 week of initiating treatment, investigate further for an underlying cause which requires treatment.
{{Learning
|literature search = [http://www.cabdirect.org/search.html?q=%28%28+title%3A%28%22Immune+Mediated%22%29++AND++%28+title%3A%28%22Thrombocytopaenia%22%29++OR++title%3A%28%22thrombocytopenia%22%29+%29+%29++OR+++%28+%28+title%3A%28Idiopathic%29+++AND++%28+title%3A%28%22Thrombocytopaenic%22%29+++OR++title%3A%28%22thrombocytopenic%22%29+%29+++AND++title%3A%28Purpura%29+%29+%29%29&fq=sc%3A%22ve%22 Immune Mediated Thrombocytopaenia publications]
}}
==References==
==References==
Ettinger, S.J, Feldman, E.C. (2005) '''Textbook of Veterinary Internal Medicine''' (6th edition, volume 2) Elsevier Saunders Company
Ettinger, S.J, Feldman, E.C. (2005) '''Textbook of Veterinary Internal Medicine''' (6th edition, volume 2) Elsevier Saunders Company
{{review}}
[[Category:Antibody Mediated Autoimmune Diseases]]
[[Category:Antibody Mediated Autoimmune Diseases]]
[[Category:Immunological Diseases - Dog]][[Category:Lymphoreticular and Haematopoietic Diseases - Dog]][[Category:Immunological Diseases - Cat]][[Category:Lymphoreticular and Haematopoietic Diseases - Cat]][[Category:Expert Review]]
[[Category:Immunological Diseases - Dog]][[Category:Lymphoreticular and Haematopoietic Diseases - Dog]][[Category:Immunological Diseases - Cat]][[Category:Lymphoreticular and Haematopoietic Diseases - Cat]][[Category:Expert Review]]