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<FlashCard questions="11">
 
<FlashCard questions="11">
|q1=What is a prion (PrP)?
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|q1=What causes actinobacillosis in pigs?
|a1=
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|a1= ''Actinobacillus suis'' - a beta-haemolytic Gram-negative bacterium.
A prion (PrP) is a protein that occurs normally in the nervous and lymphoreticular tissues.  When is changes conformation (PrP<sup>sc</sup>/PrP<sup>Res</sup>) it becomes an infectious agent and causes degeneration of neurological tissue.
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|l1=Actinobacillus suis#Introduction
|l1=Bovine Spongiform Encephalopathy#Introduction
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|q2=Is actinobacillosis a zoonosis?
|q2=How are cattle exposed to BSE?
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|a2=It is not considered a zoonosis but there has been a report of human infection after a pig bite
|a2=
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|l2=Actinobacillosis - Pig#Introduction
Through the feeding of ruminant-derived protein within feedstuffs such as meat and bone meal (MBM).
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|q3=What herds are more susceptible to ''A.suis''?
|l2=Bovine Spongiform Encephalopathy#Introduction
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|a3=High health status herds with lower immune challenges.
|q3=What is the average incubation time of BSE?
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|l3=Actinobacillosis - Pig#Signalment
|a3=
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|q4=What environmental factors can exacerbate this disease?
4-5 years
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|l3=Bovine Spongiform Encephalopathy#Signalmet
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|q4=What are the main clinical signs of BSE in cattle?
   
|a4=
 
|a4=
* Progressive neurological and behavioural changes
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*Temperature fluctuation
* Changes in sensation and temperament (increased agression)
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*High humidity
* Progressive weakness and hind-limb ataxia
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*Mixing of pigs of different ages
* Decreased milk yield
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*Overcrowding
|l4=Bovine Spongiform Encephalopathy#Clinical signs
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Genetic make up and immune status can also influence infectivity rate and clinical signs.
|q5=What area of the brain do prions mainly accumulate in?
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|l4=Actinobacillosis - Pig#Signalmet
|a5= In the medulla oblongata (Obex)
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|q5=What age ranges of pigs are affected by this disease?
|l5=Bovine Spongiform Encephalopathy#Diagnosis
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|a5= The disease affects suckling, weanling and fattening pigs, and adult pigs and it is thought that it colonises piglets within the first three weeks of life.
|q6=Can serological tests be used for BSE?
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|l5=Actinobacillosis - Pig#Introduction
|a6= No, because BSE does not cause an immune or inflammatory response.
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|q6=What clinical signs can be associated with actinobacillosis?
|l6=Bovine Spongiform Encephalopathy#Diagnosis
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|a6=  
|q7=How is BSE diagnosed?
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* Lethargy, depression, '''erysipelas-like lesions''', abscesses, haemorrhage, vomiting/regurgitation and '''lameness''', '''multiple joint swelling''', dysphagia, lymphadenopathy, '''anorexia''', unthriftiness, '''pneumonia''' and '''sudden death'''
|a7=  
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*'''Cardiorespiratory signs:''' tachycardia, murmurs, changes in heart rate, purulent or serous occulonasal discharges, sneezing, coughing, abnormal lung sounds, dyspnoea, '''cyanosis''' and open mouthed breathing
* Observation of clinical signs
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*'''Aural purulent mucoid discharge''',rubbing and scratching their ears and deafness
* Postmortem and the presence of bilateral symmetrical vacuolation in the grey matter
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*Neurological signs such as head tilt, circling, '''temors''', '''paraparesis''' and '''ataxia'''
* Western Blot Test (detection of PrP<sup>Res</sup>)
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*Ocular signs such as '''corneal oedema''' and '''ulceration'''
* Elisa Test
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In '''sows''' it can cause '''agalactia, mastitis, abortions, still births''' or '''weak piglets'''.
|l7=Bovine Spongiform Encephalopathy#Diagnosis
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|l6=Actinobacillosis - Pig#Clinical Signs
|q8=What are the most important control measures for BSE?
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|q7=How can ''actinobacillus'' be diagnosed?
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|a7= By the isolation of ''A. suis'', from '''culturing infected tissue'''.
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|l7=Actinobacillosis - Pig#Diagnosis
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|q8=What can be seen on post mortem with this disease?
 
|a8=  
 
|a8=  
* The 1988 feed ban prohibiting the feeding of ruminant derived meat and bone meal (MBM) to ruminants
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*Serous or '''fibrinous exudates''' in the thorax and pericardium
* Post mortem testing schemes
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*'''Ecchymotic haemorrhages''' in kidneys, lungs, liver, spleen and other organisms
* Culling of infected cohort animals
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|l8=Actinobacillosis - Pig#Diagnosis
|l8=Bovine Spongiform Encephalopathy#Diagnosis
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|q9=What are the differential diagnosis for ''actinobacillosis'' in pigs?
|q9=Is BSE a zoonosis?
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|a9=  
|a9= Yes, there is evidence to suggest that humans are at risk of developing variant Creutzfeldt-Jakob Disease (vCJD)from eating BSE infected meat.
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*Actinobacillus pleuropneumoniae
|l9=Bovine Spongiform Encephalopathy#Control
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*Erysipelas
|q10= What measures have been put in place to reduce the risk of humans developing variant Creutzfeldt-Jakob Disease (vCJD)?
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*Glasser's Disease
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*Streptococcus suis
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*Mulberry Heart Disease
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|l9=Actinobacillosis - Pig#Diagnosis
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|q10=How is actinobacillosis in pigs treated?
 
|a10=  
 
|a10=  
*All visible nervous and lymphatic tissue that are classified as '''specified risk materials (SRM)''' are removed during the processing of cattle
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*'''Ceftioufur, gentamicin''' and '''trimethoprim/sulfadiazine''' (good sensitivity)
*The removal of any suspect animals from the human food chain. 
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*Ampicillin, neomycin, sulfadimethoxine and tiamulin (moderate sensitivity)
*In 1996, cattle over the age of 30 months were eliminated from the food chain within the UK under the '''‘over thirty months scheme’''' (OTMS).  This ban has now been lifted and it is now compulsory to test all cattle over the age of 48months for BSE.
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Culture and sensitivity is recommended.
|l10=Bovine Spongiform Encephalopathy#Control
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|l10=Actinobacillosis - Pig#Treatment
|q11=What are the specified risk material (SRM) for cattle?
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|q11=How is actinobacillosis in pigs controlled?
 
|a11=  
 
|a11=  
*Brain
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Currently there is no commercial vaccine for ''A. suis''.  '''Routine biosecurity''' and '''disinfection''' should be followed and maintained. 
*Eyes (retina)
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|l11=Actinobacillosis - Pig#Control
*Trigeminal ganglia
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*Spinal cord
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*Dorsal root ganglia
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*Mesentery
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*Intestines (duodenum to rectum)
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*Tonsils
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|l11=Bovine Spongiform Encephalopathy#Control
   
</FlashCard>
 
</FlashCard>
    +
==Further links==
 +
[[Actinobacillus suis| Actinobacillus suis'']]
    +
[[Actinobacillus suis Flashcards| ''Actinobacillus suis'' Flashcards]]
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[[Category: Pig Flashcards]]
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[[Category:Pig Flashcards]]
 
[[Category:CABI Flashcards]]
 
[[Category:CABI Flashcards]]
[[Category: To Do - Jaimie Meagor]]
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[[Category:Respiratory Diseases Flashcards]] [[Category:Integumentary Diseases Flashcards]] [[Category:Neurological Diseases Flashcards]] [[Category:Reproductive Diseases Flashcards]]
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