Changes

'''''Also Known As – Goose Hepatitis – Goose Parvovirus – Goose Plague – Goose Viral Enteritis – Goose Viral Hepatitis – Gosling Plague'''''

Also Known As: '''''Goose Hepatitis — Goose Plague — Goose Viral Enteritis — Goose Viral Hepatitis — Gosling Plague'''''

Caused By – ''Goose Parvovirus – GPV -  Muscovy Duck Parvovirus - MDPV''

Caused By: '''''Goose Parvovirus — GPV — Muscovy Duck Parvovirus — MDPV''

==Introduction==

==Introduction==

Derzsy’s disease is a '''highly contagious [[Alimentary System|gastrointestinal disease]] of young geese and Muscovy ducks''', caused by a '''parvovirus. '''

Derzsy’s disease is a '''highly contagious gastrointestinal disease of young geese and Muscovy ducks''', caused by a [[:Category:Parvoviridae|'''parvovirus. ''']]

There are antigenic and genetic differences between the two viruses but the disease presentation is identical and both viruses can affect both species although susceptibility varies.   

There are antigenic and genetic differences between the two viruses but the disease presentation is identical and both viruses can affect both species although susceptibility varies.   

==Distribution==

==Distribution==

Derzsy’s is widespread across '''Asia, Europe, Russia, the UK and also present in California.'''

Derzsy’s is widespread across '''Asia, Europe, Russia, the UK and is also present in California.'''

Infected birds '''shed virus faecally''' in large amounts resulting in rapid direct and indirect transmission. Horizontal transmission also occurs via '''water and feed''' contaminated by diseased birds.

Infected birds '''shed virus faecally''' in large amounts resulting in rapid direct and indirect transmission. Horizontal transmission also occurs via '''water and feed''' contaminated by diseased birds.

==Diagnosis==

==Diagnosis==

Virus isolation van be achieved by '''innoculation of goose or duck eggs''' from post-mortem samples. Mortality of the embryos occurs after 5-10 days and the '''livers become ochre coloured'''. Embryonic cell cultures can also be used for isolation. Intranuclear inclusions and syncytium formations can be seen on preparations of these primary cell cultures under microscopy.  

Virus isolation can be achieved by '''innoculation of goose or duck eggs''' from post-mortem samples. Mortality of the embryos occurs after 5-10 days and the '''livers become ochre coloured'''. Embryonic cell cultures can also be used for isolation. Intranuclear inclusions and syncytium formations can be seen on preparations of these primary cell cultures under microscopy.  

'''Immunofluorescence, electron microscopy, virus neutralisation, immunoperoxidase and indirect haemagglutination'''  can then be used to confirm viral identity.  

'''[[Immunofluorescence]], electron microscopy, virus neutralisation, immunoperoxidase and indirect [[Agglutination|haemagglutination]]'''  can then be used to confirm viral identity.  

'''PCR''' is now available and is very sensitive. This technique can also tell the two viruses apart.

'''PCR''' is now available and is very sensitive. This technique can also tell the two viruses apart.

==Control==

==Control==

Due to transmission from congenitally infected eggs and goslings, '''incubating and hatching egs from different flocks together should be avoided'''. Only eggs from known GPV-free flocks should be hatched together and hatchery hygiene should be well maintained.

Due to transmission from congenitally infected eggs and goslings, '''incubating and hatching eggs from different flocks together should be avoided'''. Only eggs from known GPV-free flocks should be hatched together and hatchery hygiene should be well maintained.

Any '''survivors of outbreaks should not be used for breeding''' as they may be latent carriers. Any incontact geese should be serologically tested and removed from the flock if positive.  

Any '''survivors of outbreaks should not be used for breeding''' as they may be latent carriers. Any incontact geese should be serologically tested and removed from the flock if positive.  

'''Passive immunisation''' usiny hyperimmune serum is also possible in freshly hatched goslings but is expensive and time consuming, often requiring two doses.

'''Passive immunisation''' using hyperimmune serum is also possible in freshly hatched goslings but is expensive and time consuming, often requiring two doses.

'''Active immunisation''' of adults with virulent virus has also been reported and protection is transferred to their progeny via the yolk. There are also '''attenuated and inactivated vaccines''' available but the latter should only be used for prophylaxis in flocks where GPV has not been diagnosed.

'''Active immunisation''' of adults with virulent virus has also been reported and protection is transferred to their progeny via the yolk. There are also '''attenuated and inactivated vaccines''' available but the latter should only be used for prophylaxis in flocks where GPV has not been diagnosed.

Animal Health & Production Compendium, '''Derzsy’s Disease datasheet''', accessed 20/07/2011 @ http://www.cabi.org/ahpc/

Animal Health & Production Compendium, '''Derzsy’s Disease datasheet''', accessed 20/07/2011 @ http://www.cabi.org/ahpc/

[[Category:To Do - CABI review]]

 

[[Category:CABI Expert Review]]

[[Category:Parvoviridae]]

[[Category:Alimentary Diseases - Birds]]

[[Category:Alimentary Diseases - Birds]]