Changes

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PGF2α is produced by the placenta in responce to the production of fetal corticoids. (PGF2α also helps to remove the progesterone block pre-parturition.) PGF2α is not thought to act directly on the cervix and instead causes the myometrium of the uterus to become more active resulting in increased cervical stimulation and therefore softening and dilation. PGE2 is maternally derived and is the main driver of cervical softening. The production of PGE2 coincides with reductions in progesterone levels. PGE2 also acts on the uterus resulting in increased myometrial contractions, increased uterine pressure and therefore also cervical stimulation. PGI2

PGF2α is produced by the placenta in response to the production of fetal corticoids. (PGF2α also helps to remove the progesterone block pre-parturition.) PGF2α is not thought to act directly on the cervix and instead causes the myometrium of the uterus to become more active resulting in increased cervical stimulation and therefore softening and dilation. PGE2 is maternally derived and is the main driver of cervical softening. The production of PGE2 coincides with reductions in progesterone levels. PGE2 also acts on the uterus resulting in increased myometrial contractions, increased uterine pressure and therefore also cervical stimulation. PGI2 is also maternally derived and acts as a vasodilator and as an anticoagulant, playing another important role in cervical relaxation. With all types of prostaglandin, isoforms are produced locally and act locally and are therefore not strictly classed as hormones.

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