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|book = Cytology Q&A}}

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'''A six-year-old female spayed DSH cat presented for chronic weight loss and a recent history of vomiting and severe lethargy. Physical examination revealed pale, icteric mucous membranes. The temperature was 38°C (100.4°F) and pulse and respiration rates were slightly increased. Abdominal palpation and radiographs revealed diffuse hepatomegaly. Examination of a peripheral blood smear indicated RBC shape abnormalities including severe acanthocytosis. Abnormal biochemistry values were: AST = 150 U/l (ref. = 2–36 U/l); ALT = 350 U/l (ref. = 6–80 U/l); ALP = 135 U/l (ref. = 2–43 U/l); bilirubin = 68 μmol/l (ref. = 0–3.4 μmol/l). An FNA of the liver was obtained and a smear made (29a) (Wright–Giemsa, ×25).'''

'''A six-year-old female spayed DSH cat presented for chronic weight loss and a recent history of vomiting and severe lethargy. Physical examination revealed pale, icteric mucous membranes. The temperature was 38°C (100.4°F) and pulse and respiration rates were slightly increased. Abdominal palpation and radiographs revealed diffuse hepatomegaly. Examination of a peripheral blood smear indicated RBC shape abnormalities including severe acanthocytosis. Abnormal biochemistry values were: AST = 150 U/l (ref. = 2–36 U/l); ALT = 350 U/l (ref. = 6–80 U/l); ALP = 135 U/l (ref. = 2–43 U/l); bilirubin = 68 μmol/l (ref. = 0–3.4 μmol/l). An FNA of the liver was obtained and a smear made (Wright–Giemsa, ×25).'''

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*Abundant punctate vacuoles are also noted in the background.  

*Abundant punctate vacuoles are also noted in the background.  

*The cytological interpretation is vacuolar degeneration compatible with hepatic lipidosis.

*The cytological interpretation is vacuolar degeneration compatible with hepatic lipidosis.

|l2=Hepatic Lipidosis#Diagnosis

|l2=Hepatic Lipidosis#Pathology

|q3=List the differentials for your diagnosis, and discuss treatment options.

|q3=List the differentials for your diagnosis, and discuss treatment options.

|a3=Hepatic lipidosis in cats may be a primary disease or may occur secondary to other metabolic, inflammatory or neoplastic conditions. Approximately 50% of cases are idiopathic. <br><br>

|a3=Hepatic lipidosis in cats may be a primary disease or may occur secondary to other metabolic, inflammatory or neoplastic conditions. Approximately 50% of cases are idiopathic. <br><br>

Because these cats are already ill and stressed, extreme care must be taken not to cause further stress by force-feeding.<br><br>

Because these cats are already ill and stressed, extreme care must be taken not to cause further stress by force-feeding.<br><br>

Note: An additional photomicrograph is included here for comparison (29b) (Wright–Giemsa, ×100 oil). The multiple small, crisply defined cytoplasmic vacuoles within hepatocytes are characteristic of this condition.

Note: An additional photomicrograph is included here for comparison (29b) (Wright–Giemsa, ×100 oil). The multiple small, crisply defined cytoplasmic vacuoles within hepatocytes are characteristic of this condition.

|l3=Hepatic Lipidosis

|l3=Hepatic Lipidosis#Treatment

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