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Created page with "{{Template:Manson Sparkes}} [[Image:|centre|500px]] <br /> '''The graph shows the blood glucose results obtained from a 6 kg diabetic cat which is being treated in hospital wi..."
{{Template:Manson Sparkes}}

[[Image:|centre|500px]]

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'''The graph shows the blood glucose results obtained from a 6 kg diabetic cat which is being treated in hospital with 20 U of lente insulin once daily. Normal blood glucose concentrations would be between 3.5–7.5 mmol/l (63–135 mg/dl).'''

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<FlashCard questions="2">
|q1=What is the assessment of this case?
|a1=
The glucose curve suggests that the cat is insulin resistant. <br><br>
Insulin resistance is usually defined as being present in cats remaining hyperglycaemic and glycosuric in spite of receiving >1.5 U of insulin per kg bodyweight per dose, or in cats requiring >2.2 U/kg to maintain glycaemic control.
|l1=
|q2=What differential diagnoses need to be considered?
|a2=
Mild insulin resistance can be seen with a variety of physiological and pathological conditions including dioestrus, pregnancy, and severe obesity. <br><br>
Concurrent diseases of an inflammatory, infectious, hormonal, or neoplastic nature may all contribute to poor stabilization via secretion of diabetogenic hormones (glucagon, adrenaline, cortisol, growth hormone). <br><br>
Common concurrent diseases include
*urinary tract infections,
*ketoacidosis,
*hyperthyroidism,
*pancreatitis, and
*chronic renal failure. <br><br>
Affected cats generally demonstrate variable or continuously poor control of their diabetes. <br><br>
Acromegaly and HAC are important causes of more severe insulin resistance. Other endocrine tumours (islet cell glucagonoma, phaeochromocytoma) are rare potential causes of marked insulin resistance. <br><br>
Improper storage and handling of insulin may also be a cause of apparent insulin resistance.
|l2=
</FlashCard>

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