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|q2=How could this be confirmed and treated?

|q2=How could this be confirmed and treated?

|a2=

|a2=

A PLN can be confirmed by evaluating urine protein loss with a UPC. In healthy cats the UPC is <0.5, and in cats with PLN it is typically >3 and may be >10. The UPC has to be interpreted with caution with lower urinary tract inflammation/bleeding. Renal biopsy could confirm immune-mediated glomerulonephritis. Treatment involves searching for and removing the inciting cause where possible (underlying infection, neoplasia, drug therapy). Many cases are idiopathic and require symptomatic therapy which is controversial. Diuretic use should be avoided. Protein supplementation is contraindicated, and glucocorticoids are generally unhelpful. Protein restriction is not valuable unless the disease has progressed to renal failure. ACE inhibitors (ramipril, enalapril, benazepril) have proven efficacy in canine glomerulonephritis, reducing proteinuria and improving clinical response, and are likely to be beneficial in cats also. Non-steroidal anti-inflammatories (e.g. aspirin) may help by reducing inflammation and any tendency for clotting due to anti-thrombin III loss.

A PLN can be confirmed by evaluating urine protein loss with a UPC.  

 

In healthy cats the UPC is <0.5, and in cats with PLN it is typically >3 and may be >10. The UPC has to be interpreted with caution with lower urinary tract inflammation/bleeding.  

 

Renal biopsy could confirm immune-mediated glomerulonephritis.  

 

Treatment involves searching for and removing the inciting cause where possible (underlying infection, neoplasia, drug therapy). Many cases are idiopathic and require symptomatic therapy which is controversial.  

 

Diuretic use should be avoided. Protein supplementation is contraindicated, and glucocorticoids are generally unhelpful. Protein restriction is not valuable unless the disease has progressed to renal failure.  

 

ACE inhibitors (ramipril, enalapril, benazepril) have proven efficacy in canine glomerulonephritis, reducing proteinuria and improving clinical response, and are likely to be beneficial in cats also.  

 

Non-steroidal anti-inflammatories (e.g. aspirin) may help by reducing inflammation and any tendency for clotting due to anti-thrombin III loss.

|l2=Glomerulonephritis

|l2=Glomerulonephritis

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