Changes

==Patterns of Fibrosis ==

==Patterns of Fibrosis ==

===Centrilobular (periacinar) Fibrosis===

===Centrilobular (periacinar) Fibrosis===

This involves fibrosis around  the hepatic venule (centrilobular vein). It is associated with chronic toxic injury since hepatocytes in this region are involved in drug metabolism. It is also associated with chronic passive congestion due to long-term [[Hear Failure, Right-Sided|right sided congestive heart failure]].

This involves fibrosis around  the hepatic venule (centrilobular vein). It is associated with chronic toxic injury since hepatocytes in this region are involved in drug metabolism. It is also associated with chronic passive congestion due to long-term [[Heart Failure, Right-Sided|right sided congestive heart failure]].

   

   

===Periportal (biliary) Fibrosis===

===Periportal (biliary) Fibrosis===