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Spindle cells are of '''mesenchymal origin''', and form the body's connective tissue, fat, muscle, bone, cartilage and blood vessels.
Spindle cells are of '''mesenchymal origin''', and form the body's connective tissue, fat, muscle, bone, cartilage and blood vessels.
Spindle cell tumours can be benign or malignant, and will arise from these different cell lines.
The name 'spindle cell' refers to the shape of the cell on cytology and histology.
Spindle cell tumours can be '''benign (suffix -oma)''' or '''malignant (suffix -sarcoma)''', and will arise from these different cell lines.
It can be '''difficult to differentiate''' between the different forms of spindle cell tumours, and also to distinguish between spindle cell neoplasia and a fibroplastic spindle cell proliferative response.
It can be '''difficult to differentiate''' between the different forms of spindle cell tumours, and also to distinguish between spindle cell neoplasia and a fibroplastic spindle cell proliferative response.
Common cytological findings for '''benign''' spindle cell tumours include: small spindle-shaped cells, small nuclei, minimal anisocytosis.
Common cytological findings for '''benign''' spindle cell tumours include: small spindle-shaped cells, small nuclei, minimal anisocytosis.
Cyological findings for '''soft tissue sarcomas''' include:
Cyological findings for '''sarcomas''' include:
:large, plump spindle cells
:large, plump spindle cells
:large nuclei and prominent nucleoli
:large nuclei and prominent nucleoli
'''Benign forms''' are usually well circumscribed and can be surgically removed with an '''excellent prognosis'''.
'''Benign forms''' are usually well circumscribed and can be surgically removed with an '''excellent prognosis'''.
'''Malignant forms''' are often '''highly infiltrative and locally aggressive''', with a high likelihood of '''recurrence'''. '''Wide surgical excision''' is the treatment of choice.
'''Sarcomas''' are often '''highly infiltrative and locally aggressive''', with a high likelihood of '''recurrence'''. '''Wide surgical excision''' is the treatment of choice.
They metastasise rarely (apart from [[Haemangiosarcoma|haemangiosarcomas]]).
They metastasise rarely (apart from [[Haemangiosarcoma|haemangiosarcomas]]).