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In the female '''alpha-fetoprotein''' binds to estradiol which has been secreted by the fetal ovary. This binding results in the complex being unable to cross the [[Blood_Brain_Barrier_-_Anatomy_%26_Physiology|blood brain barrier]]. This mechanism protects the female brain from the masculinising effects of estradiol and allows the development of a 'feminising' '''surge centre''' at the point of the rostral part of the [[Midbrain_-_Anatomy_%26_Physiology|mesencephalon]].
 
In the female '''alpha-fetoprotein''' binds to estradiol which has been secreted by the fetal ovary. This binding results in the complex being unable to cross the [[Blood_Brain_Barrier_-_Anatomy_%26_Physiology|blood brain barrier]]. This mechanism protects the female brain from the masculinising effects of estradiol and allows the development of a 'feminising' '''surge centre''' at the point of the rostral part of the [[Midbrain_-_Anatomy_%26_Physiology|mesencephalon]].
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==Normal Sexual Development==
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Throughout normal sexual development there are series of defined phases;
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===Pregonadal Phase===
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===Bipotential Gonadal Phase===
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===Pimary Sexual Differentiation Phase===
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===Secondary Sexual Differentiation Phase===
    
==EMBRYOLOGICAL DEVELOPMENT OF THE GENITAL TRACT==
 
==EMBRYOLOGICAL DEVELOPMENT OF THE GENITAL TRACT==
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