Reductions in renal output allow ketone bodies and glucose to increase to ever higher concentrations in the blood. Water moves from the intracellular space to compensate for this high plasma osmolality and the alterations in cellular hydration may result in comas or seizures. | Reductions in renal output allow ketone bodies and glucose to increase to ever higher concentrations in the blood. Water moves from the intracellular space to compensate for this high plasma osmolality and the alterations in cellular hydration may result in comas or seizures. |