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Neurons - Anatomy & Physiology (view source)

Revision as of 07:36, 25 August 2011

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→‎Endothelial Cells and the Blood Brain Barrier
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==Endothelial Cells and the [[Blood Brain Barrier - Anatomy & Physiology|Blood Brain Barrier]]==
 
==Endothelial Cells and the [[Blood Brain Barrier - Anatomy & Physiology|Blood Brain Barrier]]==
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The walls of capillaries within the CNS are formed by endothelial cells, as for capillaries elsewhere in the body.
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[[Image:WIKIVETperipheralnervestructure.jpg|thumb|right|150px|Peripheral Nerve Structure © Sophie Stenner, RVC, 2008]]
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* However, in the CNS capillary endothelial cells are very tightly packed.
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The walls of capillaries throughout the body and within the CNS are formed by endothelial cells, however, within the CNS the capillary endothelial cells are very tightly packed. This density of cells restricts the passage of substances out of the bloodstream much more than endothelial cells in capillaries elsewhere in the body. This is the basis of the [[Blood Brain Barrier - Anatomy & Physiology|blood brain barrier]].
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** This density of cells restricts passage of substances out of the bloodstream much more than endothelial cells in capillaries elsewhere in the body.
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*** This is the basis of the [[Blood Brain Barrier - Anatomy & Physiology|blood brain barrier]]
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Structure and Function:
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[[Image:WIKIVETperipheralnervestructure.jpg|thumb|right|150px|Peripheral Nerve Structure © Sophie Stenner, RVC, 2008]]
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*Nerve fibres reside in a connective tissue matrix called the '''endoneurium''' and are gathered together into bundles or fascicles defined by a second connective tissue layer called the '''perineurium'''.
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*Groups of fascicles are then gathered together in a third connective tissue layer called the '''epineurium'''.
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*Thus, peripheral nerves have a '''three-tiered hierarchical arrangement of connective tissue'''.
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*Renaut bodies are loose, cigar-shaped whorls of extracellular matrix within fascicles. They are common in [[Equine Alimentary System  - Anatomy & Physiology|horse]] nerves and may also occur in human and rat peripheral nerves at points of stress or compression.
       
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