*Horizontally via faecal-oral route (main route of infection)
*Horizontally via faecal-oral route (main route of infection)
*Vertical transmission from infected layer to their chicks
*Vertical transmission from infected layer to their chicks
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*The virus replicates in the epithial cells of the alimentary tract and is circulated in the bloodstream to other organs and the central nervous system (CNS). The virus is shed within 3 days of oral ingestion and in young chicks can continue to be shed for over two weeks. Shedding ceases once specific antibody's are produced.
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*The virus replicates in the epithial cells of the alimentary tract and is circulated in the bloodstream to other organs and the central nervous system (CNS). The virus is shed within 3 days of oral ingestion and in young chicks can continue to be shed for over two weeks. Shedding ceases once specific antibodies are produced.