Author, Donkey, Bureaucrats, Administrators
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===Overview===
===Overview===
*Systemic infections - controlled by live monotypic vaccination
*Systemic infections - controlled by '''live monotypic vaccination'''
*Respiratory infections - not controled by live monotypic vaccinations
*Respiratory infections - ''not'' controled by '''live monotypic vaccinations'''
===Classification===
===Classification===
===Virus properties===
===Virus properties===
====Structure====
*Negative sense '''RNA''', unsegmented, single stranded
**-> '''Reasortment''' and '''antigenic shift''' cannot occur
*'''HN spike''' contains:
**'''Haemagglutinin (H)'''- attachment protein
**'''Neuraminidase (N)'''
*'''Fusion''' glycoprotein (F) spike
**-> Viral lipid bilayer can fuse directly with host plasma membrane
***-> RNA released into cytoplasm
**->Syncytium (multinucleated giant cells) in lesions and cell culture
**Host antibody response to this protein is most important
***Best induced by '''live attenuated vaccines'''