Changes

**Smelly sometimes bloody diarrhoea

**Smelly sometimes bloody diarrhoea

**Eruptions on the skin including hyperkeratosis of the nose and pads (hardpad)

**Eruptions on the skin including hyperkeratosis of the nose and pads (hardpad)

**Demyelination (especially in cerebellum) -> incoordination or muscle tremors -> paralysis and coma or convulsions -> death

**[[PNS Repsonses to Injury#Segmental Demyelination|Demyelination]] (especially in cerebellum) -> incoordination or muscle tremors -> paralysis and coma or convulsions -> death

**Encephalitis

**Encephalitis

**Secondary pyogenic infections associated with immunosuppression and damage to epithelia

**Secondary pyogenic infections associated with immunosuppression and damage to epithelia