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491 bytes added ,  17:21, 21 December 2007
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**LT is an oligometric toxin composed of an enzymatically-active A subunit (30KDa; 2 fragments - A1 and A2) and 5 identical B subunits (12KDa) forming the binding portion (B oligomer)
 
**LT is an oligometric toxin composed of an enzymatically-active A subunit (30KDa; 2 fragments - A1 and A2) and 5 identical B subunits (12KDa) forming the binding portion (B oligomer)
 
**It attaches to the brush border of the epithelial cells of the small intestine
 
**It attaches to the brush border of the epithelial cells of the small intestine
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**LT causes ADP-ribosylation of the stimulatory subunit of guanine nucleotide binding proteins of the adenylate cyclase complex in eukaryotic cell membranes
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**This causes irreversible activation of adenylate cyclase in target cells
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**This raises the cAMP level and causes hypersecretion of water and chloride ions into the lumen of the small intestine and inhibits reabsorption of sodium
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**The gut becomes distended with fluid and a diarrhoea which lasts several days results
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**LT is antigenic
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