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Also known as: '''''Septic Arthritis'''''
==Introduction==
==Introduction==
Infectious arthritis describes the presence in joints of a bacterial, viral or fungal infection.
Infectious arthritis describes the presence in joints of a bacterial, viral or fungal infection. This leads to '''cartilage damage''' due to the release of enzymes, the accumulation of fibrin, white blood cells and organisms. There may be the formation of pannus, which is a granulation tissue overgrowth of the cartilage surface, and a loss of glycosaminoglycans which protect the cartilage.
This leads to '''cartilage damage''' due to the release of enzymes, the accumulation of fibrin, white blood cells and organisms.
There may be the formation of pannus, which is a granulation tissue overgrowth of the cartilage surface, and a loss of glycosaminoglycans which protect the cartilage.
'''Bacterial arthritis''' occurs most commonly in food animals, especially young animals, in horses, and more rarely in small animals.
'''Bacterial arthritis''' occurs most commonly in food animals, especially young animals, in horses, and more rarely in small animals.
:'''Trauma''': from a penetrating wound, a bite
:'''Trauma''': from a penetrating wound, a bite
:'''Extension''': from adjacent tissue or bone
:'''Extension''': from adjacent tissue or bone
:'''Haematogenous''': from an umbilical infection, pneumonia, urinary tract infection, endocarditis, dermatitis, periodontal disease, discospondylitis
:'''Haematogenous''': from an umbilical infection, pneumonia, urinary tract infection, [[endocarditis]], dermatitis, [[Periodontal Disease|periodontal disease]], discospondylitis
:'''Iatrogenic''': joint injection or surgery
:'''Iatrogenic''': joint injection or surgery
==Species Differences==
==Species Differences==
'''Sheep'''
[[Retroviridae|'''Maedi visna virus''']]
*[[Retroviridae|'''Maedi visna virus''']]
*Bacterial infections mostly affects lambs except for Mycoplasmal arthritis
*[[Erysipelothrix rhusiopathiae|'''''Erysipelothrix rhusiopathiae''''']]
*'''''[[Corynebacterium pyogenes]]'''''
*[[:Category:Streptococcus species|'''''Streptococcus'' spp.''']]
*[[:Category:Staphylococcus species|'''''Staphylococci''''']]
*[[:Category:Chlamydophila species|'''''Chlamydia sp.''''']]
'''Pigs'''
*[[Erysipelas - Pig|'''''Erysipelothrix rhusiopathiae''''']]
*'''''[[Corynebacterium pyogenes]]''''' and [[:Category:Staphylococcus species|'''''Staphylococci''''']]
*'''''[[Haemophilus suis]]'' and ''[[Haemophilus parasuis]]'''''
*'''''[[Mycoplasma hyosynoviae]]'' and ''M. hyorhinis'''''
'''Cattle'''
*Neonatal polyarthritis by:
Neonatal polyarthritis by:
:[[:Category:Streptococcus species|'''''Streptococcus'' spp.''']]: via the umbilicus and also involves eyes and meninges
:[[:Category:Streptococcus species|'''''Streptococcus'' spp.''']]: via the umbilicus and also involves eyes and meninges
:[[Escherichia coli|'''''Coliforms''''']]: Localise in joints and meninges in severe non-fatal neonatal colibacillosis. The infection may remain as chronic arthritis in larger joints.
:[[Escherichia coli|'''''Coliforms''''']]: Localise in joints and meninges in severe non-fatal neonatal colibacillosis. The infection may remain as chronic arthritis in larger joints.
*Infections at any age:
Infections at any age:
:'''''[[Corynebacterium pyogenes]]''''': suppurative arthrtis, often due to a penetrating wound into or close to joints
:'''''[[Corynebacterium pyogenes]]''''': suppurative arthrtis, often due to a penetrating wound into or close to joints
:[[:Category:Mycoplasmas|'''''Mycoplasma spp.''''']]: may be responsible for some chronic cases but difficult to prove as hard to isolate, leads to a fibrinous polyarthritis
:[[:Category:Mycoplasmas|'''''Mycoplasma spp.''''']]: may be responsible for some chronic cases but difficult to prove as hard to isolate, leads to a fibrinous polyarthritis
:'''''[[Brucella abortus]]''''': uncommonly localises in joints but can occur in '''carpal bursitis ([[hygroma]]) in cattle and bursitis in horses'''.
:'''''[[Brucella abortus]]''''': uncommonly localises in joints but can occur in '''carpal bursitis ([[hygroma]]) in cattle and bursitis in horses'''.
'''Horses'''
Arthritis can occur following neonatal infections by:
*Arthritis can occur following neonatal infections by:
:'''''[[Actinobacillus equuli]]'''''
:'''''[[Actinobacillus equuli]]'''''
:[[:Category:Streptococcus species|'''''Streptococcus'' spp.''']]
:[[:Category:Streptococcus species|'''''Streptococcus'' spp.''']]
:[[Salmonella|'''''Salmonella''''']]
:[[Salmonella|'''''Salmonella''''']]
'''Goats'''
*[[Caprine Arthritis Encephalitis Virus]]
[[:Category:Streptococcus species|'''''Streptococci''''']]
'''''[[Escherichia coli]]'''''
'''Dogs'''
*[[:Category:Staphylococcus species|'''''Staphylococci''''']]
*[[:Category:Streptococcus species|'''''Streptococci''''']]
*[[:Category:Corynebacterium species|'''''Corynebacterium''''']]
*'''''[[Escherichia coli]]'''''
==Clinical Signs==
==Clinical Signs==
Infectious arthritis usually present as a '''shifting lameness''' in one or more joints.
Infectious arthritis usually presents as a '''shifting lameness''' in one or more joints.
There will be '''joint effusion, heat, periarticular swelling''', and there may be '''systemic signs''' such as fever, depression, anorexia and lymphadenopathy.
There will be '''joint effusion, heat, periarticular swelling''', and there may be '''systemic signs''' such as fever, depression, anorexia and lymphadenopathy.
==Diagnosis==
==Diagnosis==
The diagnosis is made on the basis of the clinical signs and the results of synovial fluid examination.
The diagnosis is made on the basis of the clinical signs and the results of synovial fluid examination. The '''synovial fluid''' should be collected before administering antibiotics.
The '''synovial fluid''' should be collected before administering antibiotics.
'''Culture and sensitivity''' in aerobic and anaerobic media should be performed though up to 50% of cultures will yield false-negative results. Inoculating the fluid into '''blood culture medium''' and then blood agar increases the chances of obtaining a positive result.
'''Culture and sensitivity''' in aerobic and anaerobic media should be performed though up to 50% of cultures will yield false-negative results. Inoculating the fluid into '''blood culture medium''' and then blood agar increases the chances of obtaining a positive result.
'''Radiography''' can help in the diagnosis and is essential in providing a baseline of joint anatomy to evaluate any changes that might occur down the line.
'''Radiography''' can help in the diagnosis and is essential in providing a baseline of joint anatomy to evaluate any changes that might occur down the line.
'''Contrast radiography''' may help in horses to determine if a joint has been entered by a penetrating foreign body.
[[Contrast Radiography#Contrast Studies in Horses|'''Contrast radiography''']] may help in horses to determine if a joint has been entered by a penetrating foreign body.
==Treatment==
==Treatment==
'''Antibiotics''' should be administered for a minimum of 4-6 weeks, initially broad spectrum and then depending on culture and sensitivity results.
'''[[Antibiotics]]''' should be administered for a minimum of 4-6 weeks, initially broad spectrum and then depending on culture and sensitivity results.
'''Drainage and flushing''' is mandatory. Usually open drainage is performed via an arthrotomy. This allows debridement and lavage with high volumes of isotonic fluid.
'''Drainage and flushing''' is mandatory. Usually open drainage is performed via an arthrotomy. This allows debridement and lavage with high volumes of isotonic fluid.
Exercise should be restricted for 3-4 months.
Exercise should be restricted for 3-4 months.
'''NSAIDs''' can be administered for pain, corticosteroids are contraindicated in cases of infection.
'''[[NSAIDs]]''' can be administered for pain, corticosteroids are contraindicated in cases of infection.
Chronic cases with irreversible bony damage may require '''salvage surgery''' such as arthrodesis, excision arthroplasty or amputation, especially if the pain is uncontrollable.
Chronic cases with irreversible bony damage may require '''salvage surgery''' such as arthrodesis, excision arthroplasty or amputation, especially if the pain is uncontrollable.
Merck and Co (2008) '''Merck Veterinary Manual''' ''Merial''
Merck and Co (2008) '''Merck Veterinary Manual''' ''Merial''
{{review}}
[[Category:Musculoskeletal Diseases - Dog]]
[[Category:Musculoskeletal Diseases - Cat]]
[[Category:Musculoskeletal Diseases - Horse]]
[[Category:Musculoskeletal Diseases - Cattle]]
[[Category:Musculoskeletal Diseases - Pig]]
[[Category:Musculoskeletal Diseases - Sheep]]
[[Category:Musculoskeletal Diseases - Goat]]
[[Category:Expert Review]]
[[Category:Arthritis]]
[[Category:Arthritis]]