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Also known as: '''''Addison's disease
Also known as: '''''Addison's disease
==Introduction==
==Introduction==
[[Image:Adrenal necrosis.jpg|thumb|200px|Histological section of an adrenal gland undergoing necrosis<br><small>A. Jefferies 2008</small>]]
Addison's disease occurs due to a failure to produce adequate amounts of glucocorticoid and mineralocorticoid hormones from the adrenal cortex. The majority of cases are '''primary''' and occur due to an autoimmune response directed at the endocrine cells of the adrenal glands, resulting in adrenocortical atrophy. This is an example of a [[Type IV Hypersensitivity|type IV (delayed type) hypersensitivity response]]. Smaller numbers of primary cases are caused by haemorrhage, necrosis or neoplasia within the adrenal glands. '''Secondary''' hypoadrenocorticism occurs due to a reduction in the secretion of ACTH from the anterior pituitary gland.
Addison's disease occurs due to a failure to produce adequate amounts of glucocorticoid and mineralocorticoid hormones from the adrenal cortex. The majority of cases are '''primary''' and occur due to an autoimmune response directed at the endocrine cells of the adrenal glands, resulting in adrenocortical atrophy. This is an example of a [[Type IV Hypersensitivity|type IV (delayed type) hypersensitivity response]]. Smaller numbers of primary cases are caused by haemorrhage, necrosis or neoplasia within the adrenal glands. '''Secondary''' hypoadrenocorticism occurs due to a reduction in the secretion of ACTH from the anterior pituitary gland.
{{Learning
{{Learning
|flashcards = [[Small Animal Abdominal and Metabolic Disorders Q&A 07]]
|flashcards = [[Small Animal Abdominal and Metabolic Disorders Q&A 07]]
|literature search = [http://www.cabdirect.org/search.html?it=any&q2=Addison%27s+disease&q1=Hypoadrenocorticism&calendarInput=yyyy-mm-dd&q3=Addisons+disease&occuring1=title&show=all&rowId=1&rowId=2&rowId=3&options1=AND&options2=OR&options3=OR&occuring3=title&occuring2=title&publishedend=yyyy&la=any&publishedstart=yyyy&fq=sc%3A%22ve%22&y=12&x=43 Hypoadrenocorticism publications]
}}
}}
==References==
==References==
Ettinger, S.J, Feldman, E.C. (2005) '''Textbook of Veterinary Internal Medicine''' (6th edition, volume 2) Elsevier Saunders Company
Ettinger, S.J, Feldman, E.C. (2005) '''Textbook of Veterinary Internal Medicine''' (6th edition, volume 2) Elsevier Saunders Company
{{review}}
[[Category:Cell Mediated Autoimmune Diseases]][[Category:Endocrine Diseases - Dog]][[Category:Expert Review]]
[[Category:Cell Mediated Autoimmune Diseases]][[Category:Endocrine Diseases - Dog]][[Category:Expert Review]]
[[Category:Neurological Diseases - Dog]][[Category:Immunological Diseases - Dog]]
[[Category:Neurological Diseases - Dog]][[Category:Immunological Diseases - Dog]]
[[Category:Adrenal Glands - Pathology]]
[[Category:Adrenal Glands - Pathology]]