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They can then '''penetrate''' the tissues, gaining access through skin abrasions or mucous membranes. The metatrypanosomes then multiply within the reticulo-endothelial system of the host, later '''disseminating''' throughout the organs invading host cells residing within parasitophorous vacuole. These vacuoles acidify and subsequently release '''trypomastigotes''' into the cell cytoplasm. These then develop into '''amastigotes''' which divide several times eventually transforming back into trypomastigotes that rupture the host cell. From here they may invade other cells or enter the bloodstream where the opportunity may arise to infect the insect vector. The amastigotes may also burst the host cell and invade other cells.

They can then '''penetrate''' the tissues, gaining access through skin abrasions or mucous membranes. The metatrypanosomes then multiply within the reticulo-endothelial system of the host, later '''disseminating''' throughout the organs invading host cells residing within parasitophorous vacuole. These vacuoles acidify and subsequently release '''trypomastigotes''' into the cell cytoplasm. These then develop into '''amastigotes''' which divide several times eventually transforming back into trypomastigotes that rupture the host cell. From here they may invade other cells or enter the bloodstream where the opportunity may arise to infect the insect vector. The amastigotes may also burst the host cell and invade other cells.

'''''T. cruzi''''', the trypanosome of '''most veterinary importance''', is a typical Stercorarian trypanosome and utilises the '''triatomid “kissing bug”''' as its vector.

'''''T. cruzi''''', the trypanosome of '''most human importance''', is a typical Stercorarian trypanosome and utilises the '''triatomid “kissing bug”''' as its vector among others. Disease in dogs may also occur.

''T. theileri'' is transmitted by [[Tabanidae |tabanid flies]], [[Stomoxys calcitrans |stable flies]], [[Ticks |ticks]] and [[Culicidae |mosquitoes]].

''T. theileri'' is transmitted by [[Tabanidae |tabanid flies]], [[Stomoxys calcitrans |stable flies]], [[Ticks |ticks]] and [[Culicidae |mosquitoes]].