− | The complement acts as a cascade, like the blood clotting system. It begins with the the early enzymes in the cascade binding to invading bacteria and fungi as they have an affinity for components of microbial cell membranes. This binding initiates a cascade so that the binding of one molecule will eventually lead to the fixation of millions of later molecules. SOme of the the early components act as targets for phagocytes while the later components punch holes in bacteria, causing their lysis. | + | The complement acts as a cascade, like the blood clotting system. It begins with the the early enzymes in the cascade binding to invading bacteria and fungi as they have an affinity for components of microbial cell membranes. This binding initiates a cascade so that the binding of one molecule will eventually lead to the fixation of millions of later molecules. Some of the the early components act as targets for phagocytes while the later components punch holes in bacteria, causing their lysis. |