Changes

Macrophages are important players in orchestrating the various parts of the immune response. Tissue macrophages are responsible for the trigger of the innate immune response to an injury by releasing pro-inflammatory [[Cytokines|cytokines]], in particular IL-1β, IL-6 and TNF-α, that are responsible for the activation of the endothelium of post-capillary venules that allows neutrophils and other immune cells to adhere and extravasate (move out of the blood). With interactions with [[Mast Cells|Mast cells]] they amplify the release of vasoactive peptides including histamine and bradykinin that are responsible for the five signs of inflammation (redness ('''rubor'''), heat ('''calor'''), swelling ('''tumor'''), and pain ('''dolor'''), often accompanied by loss of function).

Macrophages are important players in orchestrating the various parts of the immune response. Tissue macrophages are responsible for the trigger of the innate immune response to an injury by releasing pro-inflammatory [[Cytokines|cytokines]], in particular IL-1β, IL-6 and TNF-α, that are responsible for the activation of the endothelium of post-capillary venules that allows neutrophils and other immune cells to adhere and extravasate (move out of the blood). With interactions with [[Mast Cells|Mast cells]] they amplify the release of vasoactive peptides including histamine and bradykinin that are responsible for the five signs of inflammation (redness ('''rubor'''), heat ('''calor'''), swelling ('''tumor'''), and pain ('''dolor'''), often accompanied by loss of function).

<p>In the latter course of inflammation, it is the blood monocytes that switch the immune system from innate to adaptive (see below) by interacting with CD4+ T helper cells. </p>

<p>In the latter course of inflammation, it is the blood monocytes that switch the immune system from innate to adaptive (see above) by interacting with CD4+ T helper cells. </p>

===Chemotaxis===

===Chemotaxis===