Changes

===Immune System Regulation===

===Immune System Regulation===

Macrophages are important players in orchestrating the various parts of the immune response. Tissue macrophages are responsible for the trigger of the innate immune response to an injury by releasing pro-inflammatory [[Cytokines|cytokines]], in particular IL-1β, IL-6 and TNF-α, that are responsible for the activation of the endothelium of post-capillary venules that allows neutrophils and other immune cells to adhere and extravasate (move out of the blood). With interactions with [[Mast Cells|Mast cells]] they amplify the release of vasoactive peptides including histamine and bradykinin that are responsible for the five signs of [[Inflammation - Introduction|inflammation]]:(redness ('''rubor'''), heat ('''calor'''), swelling ('''tumor'''), and pain ('''dolor'''), often accompanied by loss of function).

Macrophages are important players in orchestrating the various parts of the immune response. Tissue macrophages are responsible for the trigger of the innate immune response to an injury by releasing pro-inflammatory [[Cytokines|cytokines]], in particular IL-1, IL-6 and TNF-α, that are responsible for the activation of the endothelium of post-capillary venules that allows neutrophils and other immune cells to adhere and extravasate (move out of the blood). With interactions with [[Mast Cells|Mast cells]] they amplify the release of vasoactive peptides including histamine and bradykinin. The cytokines IL-1, IL-6 and TNF-α along with the vasoactive peptides are responsible for the five signs of [[Inflammation - Introduction|inflammation]]:(redness ('''rubor'''), heat ('''calor'''), swelling ('''tumor'''), and pain ('''dolor'''), often accompanied by loss of function). Systemic activation of macrophages leads to the condition known as '''septic shock'''.

<p>In the latter course of inflammation, it is the blood monocytes, along with [[Dendritic Cells|dendritic cells]] that switch the immune system from innate to adaptive (see above) by interacting with CD4+ T helper cells. </p>

<p>In the latter course of inflammation, it is the blood monocytes, along with [[Dendritic Cells|dendritic cells]] that switch the immune system from innate to adaptive (see above) by interacting with CD4+ T helper cells. </p>