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MHC class I is expressed on virtually all nucleated cells and consists of a membrane-associated heavy chain bound non-covalently with a secreted light chain. The heavy chain is made up of three distinct extracellular protein domains - α1, α2 and α3. The heavy chain C - terminus is cytoplasmic.
 
MHC class I is expressed on virtually all nucleated cells and consists of a membrane-associated heavy chain bound non-covalently with a secreted light chain. The heavy chain is made up of three distinct extracellular protein domains - α1, α2 and α3. The heavy chain C - terminus is cytoplasmic.
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The light chain is known as β2-microglobulin and is similar in structure to one of the heavy chain domains. It is not membrane associated but binds to the α3-domain of the heavy chain
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The light chain is known as &beta;2-microglobulin and is similar in structure to one of the heavy chain domains. It is not membrane associated but binds to the α3-domain of the heavy chain. This domain activates [[T Cell Differentiation|T helper cells]] through the interaction with the CD4<sup>+</sup> on the cell surface of the TH cells.
 
[[Image:MHC I Structure.jpg|thumb|right|200px| Structure of MHC I molecule - Copyright Prof Dirk Werling DrMedVet PhD MRCVS]]
 
[[Image:MHC I Structure.jpg|thumb|right|200px| Structure of MHC I molecule - Copyright Prof Dirk Werling DrMedVet PhD MRCVS]]
  
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