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Major Histocompatability Complexes (view source)
Revision as of 09:10, 16 May 2012
, 09:10, 16 May 2012→MHC and the Disease Process
One consequence of this parallel evolution is that host-pathogen relationships can lead to the selection of particular MHC variants, for example:
One consequence of this parallel evolution is that host-pathogen relationships can lead to the selection of particular MHC variants, for example:
* MHC class II alleles DR13/DR1*1301 are prevalent in Central and Western Africa and impart resistance to malaria.
* MHC class II alleles DR13/DR1*1301 are prevalent in Central and Western Africa and impart resistance to malaria.
* MHC-DRB1 is prevalent in Western Europe, but rare in the Inuit populations of North America, and is associated with the clearance of hepatitis B infection in Western Europe - but Inuits have the highest incidence of hepatitis B in the world.
* MHC-DRB1 is prevalent in Western Europe, but rare in the Inuit populations of North America, and is associated with the clearance of hepatitis B infection in Western Europe, and so, perhaps unsuprisingly, Inuits have the highest incidence of hepatitis B in the world.
In humans there are also strong associations between certain alleles and some autoimmune diseases, for example:
In humans there are also strong associations between certain alleles and some autoimmune diseases, for example: