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Major Histocompatability Complexes (view source)
Revision as of 10:26, 16 May 2012
, 10:26, 16 May 2012→MHC II
==MHC II==
==MHC II==
[[File:MHC Class II Presentation.png|thumb|left|200px|MHC Class II Presentation pathway - RJ Francis, RVC, 2012]]
===Structure===
===Structure===
MHC class II is expressed mainly on [[Macrophages|macrophages]], [[T cell differentiation#Antigen Presentation by Dendritic Cells|dendritic cells]] and [[B cells|B-lymphocytes]]. MHC class II consists of membrane-associated α and β chains with each chain being a transmembrane glycoprotein. The extracellular parts of each chain have two Ig-like domains - α1 and α2, β1 and β2. The β2 domain is responsible for the activation of [[T cells|T helper cells]] through the interaction with the CD4<sup>+</sup> on the cell surface of the T helper cells. The outer domains (α1 and β1) are variable and the inner domains (α2 and β2) are constant.
MHC class II is expressed mainly on [[Macrophages|macrophages]], [[T cell differentiation#Antigen Presentation by Dendritic Cells|dendritic cells]] and [[B cells|B-lymphocytes]]. MHC class II consists of membrane-associated α and β chains with each chain being a transmembrane glycoprotein. The extracellular parts of each chain have two Ig-like domains - α1 and α2, β1 and β2. The β2 domain is responsible for the activation of [[T cells|T helper cells]] through the interaction with the CD4<sup>+</sup> on the cell surface of the T helper cells. The outer domains (α1 and β1) are variable and the inner domains (α2 and β2) are constant.
*Foreign antigen then replaces the CLIP peptide
*Foreign antigen then replaces the CLIP peptide
*The MHC II-antigen complex is then secreted to the cell surface for presentation to [[T_cells#Helper_CD4.2B|CD4<sup>+</sup> T-cells]]
*The MHC II-antigen complex is then secreted to the cell surface for presentation to [[T_cells#Helper_CD4.2B|CD4<sup>+</sup> T-cells]]
==Antigen/MHC Interaction==
==Antigen/MHC Interaction==