Changes

The '''[[Macrophages|Macrophages]]''' are important in the defence against extracellular parasites. This is because macrophages are able to secrete cytokines as well as perform phagocytosis. In this they can act as 'killer cells' through antibody-dependent cell-mediated cytotoxicity, for example specific [[Immunoglobulins|IgG]]/[[Immunoglobulins|IgE]] enhances the ability of macrophages to kill schistosomules through the interaction of Fc receptors on the surface of the macrophage.

The '''[[Macrophages|Macrophages]]''' are important in the defence against extracellular parasites. This is because macrophages are able to secrete cytokines as well as perform phagocytosis. In this they can act as 'killer cells' through antibody-dependent cell-mediated cytotoxicity, for example specific [[Immunoglobulins|IgG]]/[[Immunoglobulins|IgE]] enhances the ability of macrophages to kill schistosomules through the interaction of Fc receptors on the surface of the macrophage.

**The secretion of TNF-alpha:

**The secretion of TNF-&alpha:

***Activates other macrophages

***Activates other macrophages

***Renders hepatocytes resistant to malarial infection when in conjunction with IL-1

***Renders hepatocytes resistant to malarial infection when in conjunction with IL-1