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→Important cytokines
Cytokines primarily produced by '''macrophages''':
Cytokines primarily produced by '''macrophages''':
*GM-CSF (granulocyte macrophage colony stimulating factor)- stimulates growth and differentiation of granulocytes, macrophages, [[Neutrophils|neutrophils]] and eosinophils
*GM-CSF (granulocyte macrophage colony stimulating factor)- stimulates growth and differentiation of granulocytes, macrophages, [[Neutrophils|neutrophils]] and eosinophils
*IL-1 - stimulates TH<sub>2</sub> cells and acute phase response
*IL-1 - stimulates T<sub>H</sub>2 cells and acute phase response
*IL-6 - stimulates growth and differentiation of B and T cells and acute phase response
*IL-6 - stimulates growth and differentiation of B and T cells and acute phase response
*IL-12 - stimulates TH<sub>1</sub> cells
*IL-12 - stimulates T<sub>H</sub>1 cells
*IL-18 - stimulates IFN-gamma production by T cells and NK cells, favours Th1 response
*IL-18 - stimulates IFN-gamma production by T cells and NK cells, favours Th1 response
*TNF-α - stimulates local inflammation and endothelial activation
*TNF-α - stimulates local inflammation and endothelial activation
Cytokines primarily produced by '''TH<sub>1</sub> cells''':
Cytokines primarily produced by '''T<sub>H</sub>1 cells''':
*IL-2 - stimulates proliferation and differentiation of T cells, activates NK cells and macrophages
*IL-2 - stimulates proliferation and differentiation of T cells, activates NK cells and macrophages
*IFN-γ - activates macrophages, increases expression of MHC I and II molecules, increases antigen presentation
*IFN-γ - activates macrophages, increases expression of MHC I and II molecules, increases antigen presentation
*TNF-β - stimlulates killing mechanisms in T and B cells and endothelial activation
*TNF-β - stimlulates killing mechanisms in T and B cells and endothelial activation
Cytokines primarily produced by '''TH<sub>2</sub> cells''':
Cytokines primarily produced by '''T<sub>H</sub>2 cells''':
*IL-4 - activates B cells and [[IgE]] switch, supresses Th1 cells
*IL-4 - activates B cells and [[IgE]] switch, supresses T<sub>H</sub>1 cells
*IL-5 - stimulates eosinophil growth and differentiation
*IL-5 - stimulates eosinophil growth and differentiation
*IL-10 - suppresses macrophage functions
*IL-10 - suppresses macrophage functions