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==Adaptive Immunity==
 
==Adaptive Immunity==
Although the innate immune system provides an effective first line of defence, [[T cells|T cells]] are fundamental in the development of immunity, demonstrated using T-cell deprived mice that fail to resolve otherwise non-lethal infections of, for example, ''T. cruzi''.  
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Although the innate immune system provides an effective first line of defence, '''[[T cells|T cells]]''' are fundamental in the development of immunity, demonstrated using T-cell deprived mice that fail to resolve otherwise non-lethal infections of, for example, ''T. cruzi''.  
 
*Both CD4<sup>+</sup> and CD8<sup>+</sup> cells are required for protection, e.g CD4<sup>+</sup> cells protect against the blood stage of a Plasmodium infection (erythrocytes do not express MHC class I), while CD8<sup>+</sup> cells are required to mediate immunity against the liver stage (hepatocytes do not express MHC class II).
 
*Both CD4<sup>+</sup> and CD8<sup>+</sup> cells are required for protection, e.g CD4<sup>+</sup> cells protect against the blood stage of a Plasmodium infection (erythrocytes do not express MHC class I), while CD8<sup>+</sup> cells are required to mediate immunity against the liver stage (hepatocytes do not express MHC class II).
 
*T<sub>H</sub>1 cells are required to fight intracellular protozoa - the release of IFN-γ activates macrophages to kill the protozoa residing within them
 
*T<sub>H</sub>1 cells are required to fight intracellular protozoa - the release of IFN-γ activates macrophages to kill the protozoa residing within them
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